CD151是一种跨膜蛋白，与肿瘤进展有关，已经显示出调节各种细胞和分子机制，为恶性肿瘤做出贡献。最近，作为癌症治疗的潜在靶点，CD151在肿瘤免疫微环境（TIME）中的作用引起了关注。本综述旨在探讨CD151在TIME中的作用，重点关注治疗和临床视角。将讨论CD151在调节肿瘤细胞和免疫系统之间相互作用方面的作用，以及这些相互作用基础的分子机制的当前了解情况。还将回顾针对CD151的治疗方法的当前发展状况以及这些治疗方法的潜在临床应用。本综述概述了目前对CD151在TIME中的作用的认识，并强调CD151作为癌症治疗的治疗靶点的潜力。版权所有©2023 Elsevier B.V.出版。

CD151 is a transmembrane protein implicated in tumor progression and has been shown to regulate various cellular and molecular mechanisms contributing to malignancy. More recently, the role of CD151 in the tumor immune microenvironment (TIME) has gained attention as a potential target for cancer therapy. This review aims to explore the role of CD151 in the TIME, focusing on the therapeutic and clinical perspectives. The role of CD151 in regulating the interactions between tumor cells and the immune system will be discussed, along with the current understanding of the molecular mechanisms underlying these interactions. The current state of the development of CD151-targeted therapies and the potential clinical applications of these therapies will also be reviewed. This review provides an overview of the current knowledge on the role of CD151 in the TIME and highlights the potential of CD151 as a therapeutic target for cancer treatment.Copyright © 2023. Published by Elsevier B.V.