放射治疗联合化疗 (CCR) 目前是鼻咽癌 (NPC) 的黄金标准治疗方案。解剖学改变主要是由于体重减轻所致。我们的前瞻性研究旨在评估患者的营养状况和体重减轻的质量，以在 NPC 治疗期间调整患者的营养管理。我们在 2020 年 8 月至 2021 年 3 月期间在放射治疗科治疗了 27 例非转移性 NPC 患者的单中心前瞻性研究。在治疗开始、中期和结尾时收集了询问、体格检查和生物电阻抗测量 (体重 [W]、体重指数 [BMI]、脂肪指数 [GI] 、脂肪质量 [FM] 和无脂肪质量 [FFM]) 的数据。从中期到治疗结束的体重减轻 (中位数=-4kg [-9.4; -0.9]) 大于治疗开始到中期的体重减轻 (中位数=-2.9kg [-8.8; 1.8]) (P=0.016)。整个治疗期间的体重减轻为-6.2kg [-15.6; -2.5] (8.4%)。脂肪质量的减少在治疗开始到中期和中期到治疗结尾时相同，分别为-1.4kg [-8.5; 4.2] 和 -1.4kg [-8.2; 7.8] (P=0.4)。中期到治疗结束期间无脂肪质量的减少 (-2.5kg [-27.8; 0.5]) 大于治疗开始到中期期间的减少 (-1.1kg [-7.1; 4.7]) (P=0.014)。治疗期间的中位数无脂肪质量减少为-3.6kg [-28.1; 2.6])。我们的研究结果表明，NPC 的 CCR 治疗期间体重减轻是复杂的，不仅仅是体重的减少，还涉及身体成分的紊乱。需要由营养学家进行定期随访，以预防治疗期间的营养不良。版权所有©2023 Société française de radiothérapie oncologique (SFRO)。Elsevier Masson SAS出版。保留所有权利。

Radiation therapy with chemotherapy (CCR) is currently the gold standard treatment for nasopharyngeal carcinoma (NPC). Anatomical changes are mainly due to weight loss. Our prospective study aimed to evaluate the nutritional status and the quality of weight loss in our patients to adapt the subsequent nutritional management of patients during treatment for NPC.A prospective, single-center study of 27 patients with non-metastatic NPC treated in our oncology radiotherapy department between August 2020 and March 2021. Data from interrogation, physical examination, and bioelectrical impedancemetry (weight [W], body mass index [BMI], fat index [GI], fat mass [FM], and fat-free mass (FFM]) were collected at the beginning, the mid, and the end of treatment.Weight loss from mid to end of treatment (median=-4kg [-9.4; -0.9]) was greater than that from baseline to mid-treatment (median=-2.9kg [-8.8; 1.8]) (P=0.016). Weight loss during the entire treatment was -6.2kg [-15.6; -2.5] (8.4%). The losses of FM were identical between the beginning-mid treatment and the mid-end treatment; they were respectively -1.4kg [-8.5; 4.2] and -1.4kg [-8.2; 7.8] (P=0.4). FFM losses between the mid- and the end of treatment (-2.5kg [-27.8; 0.5]) were greater than those between baseline and mid-treatment (-1.1kg [-7.1; 4.7]) (P=0.014). Median FFM loss during treatment was -3.6kg [-28.1; 2.6]).The results of our study show that weight loss during CCR for NPC is complex and is not just about loss but about a disruption of body composition. Regular follow-ups by nutritionists are required to prevent denutrition during treatment.Copyright © 2023 Société française de radiothérapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.