受病毒性流感感染影响的癌症患者住院心血管结果。
Inpatient cardiovascular outcomes in patients with cancer affected by viral influenza infection.
发表日期：2022 Sep 02
作者：
Aakash R Sheth, Udhayvir Singh Grewal, Harsh P Patel, Sahith Reddy Thotamgari, Smit Patel, Rohan Desai, Samarthkumar Thakkar, Aristotelis Papayannis
来源：
HEART & LUNG
摘要：
流感对患有基础合并症的个体影响不成比例。长期随访研究显示患有癌症的患者患有流感死亡率更高。然而，关于癌症住院患者流感感染的住院死亡率和心血管结局的了解甚少。我们通过筛选2015年至2017年的国家住院患者样本，比较了患有癌症的患者流感感染和未感染流感的住院患者的住院死亡率和心血管结局。共识别了9,443,421次任何类型癌症的住院患者，其中14,634例感染流感，而9,252,007例未感染。进行了二级分层多元逻辑回归分析，根据年龄、性别、种族、医院类型和相关合并症进行了调整。癌症和流感组的住院死亡率较高（OR 1.08；95% CI 1.003～1.16；p=0.04），急性冠脉综合征（OR 1.74；95% CI 1.57～1.93；p<0.0001）、心房颤动（OR 1.24；95% CI 1.18～1.29；p<0.0001）和急性心衰（OR 1.41；95% CI 1.32～1.51；p<0.0001）的患病率较高。患有流感的癌症患者在住院期间死亡率和患急性冠脉综合征、心房颤动和急性心衰的患病率更高。© The Author(s) 2022. Published by Oxford University Press on behalf of Postgraduate Medical Journal. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Influenza disproportionately affects individuals with underlying comorbidities. Long-term follow-up studies have shown that patients with cancer with influenza have higher mortality. However, very little is known about the in-hospital mortality and cardiovascular outcomes of influenza infection in cancer hospitalisations.We compared the in-hospital mortality and cardiovascular outcomes in patients with cancer with and without influenza by screening the National Inpatient Sample from 2015 to 2017. A total of 9 443 421 hospitalisations with any cancer were identified, out of which 14 634 had influenza while 9 252 007 did not. A two-level hierarchical multivariate logistic regression analysis adjusted for age, sex, race, hospital type and relevant comorbidities was performed.The group with cancer and influenza had higher in-hospital mortality (OR 1.08; 95% CI 1.003 to 1.16; p=0.04), acute coronary syndromes (OR 1.74; 95% CI 1.57 to 1.93; p<0.0001), atrial fibrillation (OR 1.24; 95% CI 1.18 to 1.29; p<0.0001) and acute heart failure (OR 1.41; 95% CI 1.32 to 1.51; p<0.0001).Patients with cancer affected by influenza have higher in-hospital mortality and a higher prevalence of acute coronary syndrome, atrial fibrillation and acute heart failure.© The Author(s) 2022. Published by Oxford University Press on behalf of Postgraduate Medical Journal. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.