本研究旨在通过系统性回顾和荟萃分析，研究乳腺癌患者的非药物干预认知障碍的研究特点，并确定非药物干预的主要效果。使用关键词“乳腺癌”、“认知障碍”及其可能的变化，搜索五个电子数据库，以识别所有随机对照试验研究，截止至2022年9月30日。使用Cochrane偏倚风险工具来评估偏倚风险。使用Hedges 'g计算效应大小。探索可能影响干预效果的潜在调节因素。共纳入23项研究进行系统回顾，其中17项研究进行荟萃分析。在非药物干预方面，认知康复和体育锻炼是最常见的方法，其次是认知行为治疗。荟萃分析显示，非药物干预对注意力（g = 0.83; 95% CI: 0.14至1.52; I2 = 76%）、即刻回忆（g = 0.33; 95% CI: 0.18至0.49; I2 = 0%）、执行功能（g = 0.25; 95% CI: 0.13至0.37; I2 = 0%）和处理速度（g = 0.44; 95% CI: 0.14至0.73; I2 = 51%）等客观认知功能和主观认知功能（g = 0.68; 95% CI: 0.40至0.96; I2 = 78%）有显著影响。 干预类型和交付方式是非药物干预对认知功能影响的潜在调节变量。非药物干预可以改善正在接受癌症治疗的乳腺癌患者的主观和客观认知功能。因此，有必要通过筛选高风险癌症相关认知障碍患者，提供非药物干预。CRD42021251709 © 2023作者。

This study aimed to examine the characteristics of research conducted on nonpharmacological interventions for cognitive impairment in patients with breast cancer and identify the primary effects of nonpharmacological interventions through a systematic review and meta-analysis.Five electronic databases were searched to identify all randomized controlled trial studies until September 30, 2022, using the key terms "breast cancer," "cognitive disorders," and their possible variations. The Cochrane Risk of Bias tool was used to assess risk of bias. The effect sizes were calculated in Hedges' g. Potential moderators influencing the intervention effects were explored.Twenty-three studies were included in the systematic review, and 17 studies were included in the meta-analysis. Among the nonpharmacological interventions for patients with breast cancer, cognitive rehabilitation and physical activity were the most common, followed by cognitive behavioral therapy. The meta-analysis indicated that nonpharmacological interventions had a significant effect on attention (g ​= ​0.83; 95% CI: 0.14 to 1.52; I 2 ​= ​76%), immediate recall (g ​= ​0.33; 95% CI: 0.18 to 0.49; I 2 ​= ​0%), executive function (g ​= ​0.25; 95% CI: 0.13 to 0.37; I 2 ​= ​0%), and processing speed (g ​= ​0.44; 95% CI: 0.14 to 0.73; I 2 ​= ​51%) among objective cognitive functions, as well as subjective cognitive function (g ​= ​0.68; 95% CI: 0.40 to 0.96; I 2 ​= ​78%). Intervention type and mode of delivery were potential moderators for the effects of nonpharmacological interventions on cognitive functions.Nonpharmacological interventions can improve subjective and objective cognitive functioning among patients with breast cancer undergoing cancer treatment. Therefore, it is necessary to provide nonpharmacological interventions by screening patients at high risk of cancer-related cognitive impairment.CRD42021251709.© 2023 The Author(s).