癌症是全球死亡率最高的疾病之一，影响了大量人群。化学治疗是这种疾病最常见的治疗方式之一，而脱发则是其中最为普遍的副作用之一。本研究报告了一名患有持续化学治疗致脱发（PCIA）的患者，通过使用人胎盘间充质干细胞（MSCs）来源的细胞外富集小泡体（EVs）成功治疗。该患者为36岁女性，有侵袭性导管癌病史，接受了6次紫杉醇和阿霉素化疗。在治疗后的近18个月中，她的头发除了头皮上的一些淡毛发之外，都未再生长。之后，她每4周接受一次MSC来源的EVs头皮注射（皮下），连续3个月后完全恢复了头发的生长。该报告表明，MSC来源的EVs可能是治疗永久性化学治疗致脱发的一种可能方法；然而，进一步的研究和试验仍然是必要的。©2023 Published by Elsevier Ltd.

Cancer is among the leading causes of death worldwide and affects a considerable number of individuals. Chemotherapy is one the most common treatment for this condition and hair loss is among one of the most prevalent side effects. In this study, we report successful treatment of a patient suffering from persistent chemotherapy-induced alopecia (PCIA) with extracellular enriched vesicles (EVs) derived from human placental mesenchymal stromal cells (MSCs).The patient was a 36-year-old woman with a history of invasive ductal carcinoma, underwent six courses of chemotherapy with paclitaxel and adriamycin. Following this treatment and for almost 18 months, she, unfortunately, had no regrowth of hair except some light vellus hairs on the scalp. She then received MSC-derived EVs with scalp injection (subcutaneous) every 4 weeks for 3 continuous months at which point she presented complete regrowth of terminal hair on her scalp.This report demonstrates that MSC-derived EVs could be a possible treatment for permanent chemotherapy-induced alopecia; however, further studies and trials are necessary.©2023PublishedbyElsevierLtd.