DNA是编码蛋白质序列的序列。信使RNA从基因的DNA序列转录并翻译成蛋白质。预测DNA序列的变化如何影响信使RNA和蛋白质的数量和质量可能会很困难。 DNA易位变化可导致来自两个不同基因或同一基因不同部分的序列连接。临床上通常使用DNA测序来预测DNA变化可能如何影响蛋白质。或者，RNA测序可用作测量DNA变化对蛋白质产物影响的更直接的方法。这种测序对于识别癌症中反应靶向治疗、预后或诊断的变化非常重要。©2023美国癌症协会。

DNA is the sequence that codes for proteins. Messenger RNA is transcribed from the DNA sequence of genes and translated into protein. It can be difficult to predict how a change in the DNA sequence will affect messenger RNA and protein quantity and quality. DNA translocation changes can cause the joining of sequences from two different genes or different parts of the same gene. DNA sequencing is often used clinically to predict how DNA changes might affect proteins. Alternatively, RNA sequencing can be used as a more direct measure of the effect of DNA changes on the protein products. This sequencing is important for identifying changes in cancer that may indicate response to targeted therapy, prognosis, or diagnosis.© 2023 American Cancer Society.