背景和目的：茶多酚，如绿茶多酚，已被广泛研究作为改善心血管疾病和血压的药物，并在体外和动物研究中得到了充分研究。然而，有关绿茶消费与高血压（HTN）关联的流行病学证据并不一致。此外，这种关联尚未在一般成年人中进行前瞻性研究，特别是在年轻女性中。因此，我们设计了一项队列研究，以研究绿茶消费是否会增加绝经前妇女患高血压的风险。方法和结果：本前瞻性队列研究调查了6633名没有高血压、心血管疾病和癌症基线的绝经前女性参与者。使用经过验证的膳食频率问卷在基线上测量绿茶消费。高血压是通过SBP≥140 mmHg-1或DBP≥90 mmHg-1确认的。使用Cox比例风险回归模型研究绿茶消费与新发高血压的关联。在24,957人年的随访中发生了488例首次高血压事件（中位随访4.0年）。在调整潜在混杂变量后，绝经前女性参与者中不同绿茶消费频率的多变量危险比（95%置信区间）为几乎从不为1.00（参考），每周1杯为0.84（0.67，1.07），每周2-6杯为1.02（0.77，1.35），每天≥1杯为0.65（0.44，0.96）。结论：我们前瞻性研究的结果表明，绿茶的消费与绝经前妇女患HTN的风险降低有关。

Background and aims: Tea polyphenols, such as green tea polyphenols, have been extensively studied as agents that ameliorate cardiovascular disease and blood pressure in vitro and in animal studies. However, epidemiological evidence for the association of green tea consumption with hypertension (HTN) is inconsistent. In addition, such an association has not been prospectively examined in the general adult population, particularly among young women. Therefore, we designed a cohort study to examine whether green tea consumption increases the risk of HTN in premenopausal women. Methods and results: This prospective cohort study investigated 6633 premenopausal female participants without hypertension, cardiovascular disease, and cancer at the baseline. Green tea consumption was measured at the baseline using a validated food frequency questionnaire. Hypertension was confirmed with the SBP ≥140 mm Hg-1 or with the DBP ≥90 mm Hg-1. Cox proportional hazards regression models were used to examine the association of green tea consumption with incident hypertension. A total of 488 first incident cases of hypertension occurred during 24 957 person-years of follow-up (median follow-up of 4.0 years). After adjustment for potential confounding variables, the multivariable hazard ratios (95% confidence intervals) for incident hypertension in premenopausal female participants with different green tea consumption frequencies were 1.00 (reference) for almost never, 0.84 (0.67, 1.07) for 1 cup per week, 1.02 (0.77, 1.35) for 2-6 cups per week, and 0.65 (0.44, 0.96) for ≥1 cup per day. Conclusions: The results from our prospective study indicate that the consumption of green tea is associated with a reduced risk of HTN in premenopausal women.