饮食是心血管代谢疾病的重要可修改危险因素。植物食品包含复杂的营养物质和生物活性化合物，如(多)酚类。在流行病学研究中，富含植物性食品的饮食模式与降低心血管代谢风险相关。然而，研究并没有充分考虑（多）酚类作为其关系中介因素。在年龄为41.6 ± 18.3岁的525名健康参与者中进行了横断面分析。志愿者完成了经过验证的欧洲前瞻性饮食和癌症调查（EPIC）诺福克食物频率调查问卷（FFQ）。我们调查了富含植物性食品的饮食模式、（多）酚类摄入和心血管健康之间的关系。除不健康的以植物为基础的饮食指数（uPDI）与（多）酚类摄入呈负相关外，其他营养评分与（多）酚类的关联均为正。 ges,，正健康饮食指数（hPDI）与原花青素（r=0.39，p<0.01）和类黄酮（r=0.37，p<0.01）呈正相关。在营养评分中，DASH与舒张血压（DBP）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和非高密度脂蛋白胆固醇（Non-HDL-C）呈负相关（stdBeta -0.12到-0.10，p<0.05）。地中海-DASH干预神经退行性延迟（MIND）评分与流介质扩张（FMD，stdBeta=0.10，p=0.02）呈正相关，并与10年动脉粥样骨架心血管疾病（ASCVD）风险评分呈负相关（stdBeta=-0.12，p=0.01）。黄酮类、黄烷类、单体黄烷-3-醇、茶黄素和羟基苯甲酸的摄入量增加（stdBeta：-0.31到-0.29，p=0.02）亦呈负相关，与10年ASCVD风险评分呈负相关。黄烷类与心血管标志物如空腹血糖（FPG）（stdBeta= -0.11，p=0.04）、TC（stdBeta= -0.13，p=0.03）及胰岛β细胞功能的Homeostasis Model Assessment（HOMA）(%B)（stdBeta=0.18，p=0.04）呈显著相关。黄烷类摄入量被认为是DASH、地中海原始饮食评分（O-MED）、PDI和hPDI等富含植物食品的营养评分与TC负相关的潜在部分中介因素（比例中介= 0.01%至0.07%，p<0.05）。更高的（多）酚类摄入量，尤其是黄烷类摄入量，与更高的富含植物食品的饮食模式和良好的心血管代谢风险生化标志物相关，表明（多）酚类可能是有益作用的中介因素。

Diet is an important modifiable risk factor for cardiometabolic diseases. Plant foods contain a complex mixture of nutrients and bioactive compounds such as (poly)phenols. Plant-rich dietary patterns have been associated with reduced cardiometabolic risk in epidemiological studies. However, studies have not fully considered (poly)phenols as a mediating factor in the relationship. A cross-sectional analysis was conducted in 525 healthy participants, aged 41.6 ± 18.3 years. Volunteers completed the validated European Prospective Investigation into Diet and Cancer (EPIC) Norfolk Food Frequency Questionnaire (FFQ). We investigated the associations between plant-rich dietary patterns, (poly)phenol intake, and cardiometabolic health. Positive associations were found between (poly)phenols and higher adherence to dietary scores, except for the unhealthy Plant-based Diet Index (uPDI), which was negatively associated with (poly)phenol intake. Correlations were significant for healthy PDI (hPDI), with positive associations with proanthocyanidins (r = 0.39, p < 0.01) and flavonols (r = 0.37, p < 0.01). Among dietary scores, Dietary Approaches to Stop Hypertension (DASH) showed negative associations with diastolic blood pressure (DBP), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and non-high-density lipoprotein cholesterol (Non-HDL-C) (stdBeta -0.12 to -0.10, p < 0.05). The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) score was positively associated with flow-mediated dilation (FMD, stdBeta = 0.10, p = 0.02) and negatively associated with the 10-year Atherosclerotic Cardiovascular Disease (ASCVD) risk score (stdBeta = -0.12, p = 0.01). Higher intake of flavonoids, flavan-3-ols, flavan-3-ol monomers, theaflavins, and hydroxybenzoic acids (stdBeta: -0.31 to -0.29, p = 0.02) also showed a negative association with a 10-year ASCVD risk score. Flavanones showed significant associations with cardiometabolic markers such as fasting plasma glucose (FPG) (stdBeta = -0.11, p = 0.04), TC (stdBeta = -0.13, p = 0.03), and the Homeostasis Model Assessment (HOMA) of beta cell function (%B) (stdBeta = 0.18, p = 0.04). Flavanone intake was identified as a potential partial mediator in the negative association between TC and plant-rich dietary scores DASH, Original Mediterranean diet scores (O-MED), PDI, and hPDI (proportion mediated = 0.01% to 0.07%, p < 0.05). Higher (poly)phenol intake, particularly flavanone intake, is associated with higher adherence to plant-rich dietary patterns and favourable biomarkers of cardiometabolic risk indicating (poly)phenols may be mediating factors in the beneficial effects.