清醒脑肿瘤手术的目的是尽可能切除肿瘤、尽量减少神经和认知损伤的风险。本研究旨在通过比较术前、术后早期和术后晚期的功能情况，研究患有疑似胶质瘤的患者在清醒脑肿瘤手术后潜在的认知缺陷的发展情况，以获得更详细的时间线，帮助手术候选人了解术后认知功能的预期情况。本研究共纳入了37名患者。通过广泛的认知筛查工具，在接受认知监测的清醒脑肿瘤手术后的患者中，术前、术后数天和数月对认知功能进行了评估。认知筛查工具包括物体命名、阅读、注意力、工作记忆、抑制、抑制/转换和视知觉测试。我们进行了Friedman ANOVA组内分析。总体而言，除了抑制任务表现之外，术前认知功能、术后早期认知功能和术后晚期认知功能之间没有显著差异。手术后直接进行抑制任务时，患者的表现明显较慢，但在手术后的几个月里，它们恢复到了术前水平。清醒肿瘤手术后认知功能的时间线总体上在术后早期和晚期保持稳定，除了抑制任务在清醒脑肿瘤手术后前几天更加困难。这种更详细的认知功能时间线，结合未来的研究，可能有助于告知患者和护理人员在清醒脑肿瘤手术后的预期情况。

The purpose of awake brain tumor surgery is to maximize the resection of the tumor and to minimize the risk of neurological and cognitive impairments. The aim of this study is to gain understanding of the development of possible postoperative cognitive deficits after awake brain tumor surgery in patients with suspected gliomas, by comparing preoperative, early postoperative, and late postoperative functioning. A more detailed timeline will be helpful in informing candidates for surgery about what to expect regarding their cognitive functioning.Thirty-seven patients were included in this study. Cognitive functioning was measured by means of a broad cognitive screener preoperatively, days after surgery and months after surgery in patients who underwent awake brain tumor surgery with cognitive monitoring. The cognitive screener included tests for object naming, reading, attention span, working memory, inhibition, inhibition/switching, and visuoperception. We performed a Friedman ANOVA to analyze on group level.Overall, no significant differences were found between preoperative cognitive functioning, early postoperative cognitive functioning, and late postoperative cognitive functioning, except for performances on the inhibition task. Directly after surgery, patients were significantly slower on this task. However, in the following months after surgery, they returned to their preoperative level.The timeline of cognitive functioning after awake tumor surgery appeared overall stable in the early and late postoperative phase, except for inhibition, which is more difficult in the first days after awake brain tumor surgery. This more detailed timeline of cognitive functioning, in combination with future research, can possibly be contributing in informing patients and caregivers what to expect after awake brain tumor surgery.© 2023. The Author(s).