Parabens是一类内分泌干扰物。环境雌激素可能在肺癌的发展中起着重要作用。到目前为止，Parabens与肺癌之间的关联尚未确定。基于在中国衢州市2018年至2021年期间招募的189例病例和198例对照，我们测量了5种尿液Parabens浓度，并检查了尿液Parabens浓度与肺癌风险之间的关系。病例组中甲基Paraben(MeP) (2.1与1.8 ng/mL)，乙酰Paraben (0.98与0.66 ng/mL)，丙酰Paraben(PrP) (2.2与1.4 ng/mL)，n-丁酰Paraben(0.33与0.16 ng/mL)的中位数浓度显著高于对照组。苯甲酰Paraben的检出率在对照组和病例组分别为8％和6％，因此未在进一步分析中考虑。调整模型中发现，尿液PrP浓度与肺癌风险之间存在显著相关性 (调整后odds ratio (ORadjusted) = 2.22,95％置信区间 (CI)：1.76，2.75；Ptrend＜0.001)。在分层分析中，我们发现尿液MeP浓度与肺癌风险显着相关(最高四分位组的OR = 1.16，95％CI：1.01，1.27)。此外，与PrP浓度最低组相比，我们还观察到第二，第三和第四四分位组的尿液PrP浓度与肺癌风险相关，其中调整后OR分别为1.52 (95％CI：1.29，1.65，Ptrend = 0.007)，1.39 (95％CI：1.15，1.60，Ptrend = 0.010)和1.85 (95％CI：1.53，2.30，Ptrend = 0.001)。尿液中MeP和PrP的暴露可能与成年人的肺癌风险呈正相关。© 2023年。作者(们)已独家授权给Springer-Verlag GmbH ，德国Springer Nature的一部分。

Parabens are a family of endocrine-disrupting chemicals. Environmental estrogens may play a vital role in the development of lung cancer. To date, the association between parabens and lung cancer is unknown. Based on the 189 cases and 198 controls recruited between 2018 and 2021 in Quzhou, China, we measured 5 urinary parabens concentrations and examined the association between urinary concentrations of parabens and lung cancer risk. Cases showed significantly higher median concentrations of methyl-paraben (MeP) (2.1 versus 1.8 ng/mL), ethyl-paraben (0.98 versus 0.66 ng/mL), propyl-paraben (PrP) (2.2 versus 1.4 ng/mL), and butyl-paraben (0.33 versus 0.16 ng/mL) than controls. The detection rates of benzyl-paraben were only 8 and 6% in the control and case groups, respectively. Therefore, the compound was not considered in the further analysis. The significant correlation between urinary concentrations of PrP and the risk of lung cancer (odds ratio (OR)adjusted = 2.22, 95% confidence interval (CI): 1.76, 2.75; Ptrend < 0.001) was identified in the adjusted model. In the stratification analysis, we found that urinary concentrations of MeP were significantly associated with lung cancer risk (OR = 1.16, 95% CI: 1.01, 1.27 for the highest quartile group). Besides, comparing the second, third, and fourth quartile groups with the lowest group of PrP, we also observed urinary PrP concentrations associated with lung cancer risk, with the adjusted OR of 1.52 (95% CI: 1.29, 1.65, Ptrend = 0.007), 1.39 (95% CI: 1.15, 1.60, Ptrend = 0.010), and 1.85 (95% CI: 1.53, 2.30, Ptrend = 0.001), respectively. MeP and PrP exposure, reflected in urinary concentrations of parabens, may be positively associated with the risk of lung cancer in adults.© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.