胰腺肿瘤的患者治疗方案可能有限。胰腺肿瘤消融是一种新兴的治疗方式，可以使用内镜超声（EUS）引导进行。这种方式非常适合引导射频消融（RFA）和微波消融的能量输送。这些方法提供了一种微创、非手术的方法，用于向体内消融胰腺肿瘤。本文综述了实时超声引导下消融在处理胰腺癌和胰腺神经内分泌肿瘤中的当前数据和安全性。RFA使用热能通过凝固性坏死和蛋白变性诱导细胞死亡。研究报道使用EUS引导下RFA在全面治疗系统方法和姑息手术中治疗胰腺肿瘤的患者的总生存率增加。射频消融可能在诱导免疫调节效应方面具有相应的好处。肿瘤标志物CA19-9也被报道对RFA产生降低反应。微波消融是一种新兴的方式。RFA利用局部热能诱导细胞死亡。RFA已经通过开放、腹腔镜和放射学方式应用。现在EUS引导的方法允许RFA和微波消融在胰腺肿瘤中进行实时消融。版权所有©2023 Wolters Kluwer Health，Inc。保留所有权利。

Patients with pancreatic tumors may have limited treatment options. Pancreatic tumor ablation is a novel and emerging treatment modality which can now be performed using endoscopic ultrasound (EUS) guidance. This modality is well suited to guide energy delivery for radiofrequency ablation (RFA) and microwave ablation. These approaches provide minimally invasive, nonsurgical methods for delivering energy to ablate pancreatic tumors in situ. This review summarizes the current data and safety profile for ablation in managing pancreatic cancer and pancreatic neuroendocrine tumors.RFA uses thermal energy to induce cell death by coagulative necrosis and protein denaturation. Studies have reported increased overall survival in patients with pancreatic tumors treated with EUS-guided RFA in a multimodality systemic approach and when used in palliative surgeries. Radiofrequency ablation may have corollary benefits in inducing an immune-modulatory effect. Tumor marker carbohydrate antigen 19-9 has been reported to decrease in response to RFA. Microwave ablation is an emerging modality.RFA utilizes focal thermal energy to induce cell death. RFA has been applied through open, laparoscopic, and radiographic modalities. EUS-guided approaches are now allowing RFA and microwave ablation to be performed for pancreatic tumors in situ.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.