四个新的Cu(I)化合物，通式为[Cu(PP)(LL)][BF4]，其中PP为膦配体(三苯基膦或1,2-二(二苯基膦基)乙烷(dppe))，LL为生物活性噻氨酰半胱氨酸配体(4-(甲基)-1-(5-硝基呋喃甲醛亚胺)噻氨酰半胱氨酸或4-(乙基)-1-(5-硝基呋喃甲醛亚胺)噻氨酰半胱氨酸)。采用经典分析和光谱方法对其进行了全面表征。在Trypanossoma cruzi 和两种人类癌细胞系(卵巢OVCAR3和前列腺PC3)中，进行了体外的抗锥虫和抗癌活性研究。为了测试其对寄生虫和癌细胞的选择性，还评估了它们对正常猴肾VERO和人皮肤成纤维细胞HDF细胞的细胞毒性。新的杂合配合物对T.cruzi和化疗耐药的前列腺癌PC3细胞的毒性过于那夫鸟嘌呤和顺铂这一类基准药物。这些化合物还显示出在OVCAR3细胞中高水平的细胞内渗透性，并且特别含有dppe膦配体的化合物，表现出通过凋亡机制激活细胞死亡的能力。另一方面，这些配合物诱导的ROS产生并不明显。©2023 Wiley-VCH GmbH。

Four new Cu(I) complexes of general formula [Cu(PP)(LL)][BF4], where PP is a phosphane ligand (triphenylphosphane or 1,2-bis(diphenylphosphano)ethane (dppe)) and LL  is a  bioactive thiosemicarbazone ligand (4-(methyl)-1-(5-nitrofurfurylidene)thiosemicarbazone) or 4-(ethyl)-1-(5-nitrofurfurylidene)thiosemicarbazone) were synthesized and fully characterized by classical analytical and spectroscopic methods. The anti-trypanosome and the anticancer activities were investigated in vitro on Trypanossoma cruzi and in two human cancer cell lines (ovarian OVCAR3 and prostate PC3). To test the selectivity towards the parasites and cancer cells, the cytotoxicity on normal monkey kidney VERO and human dermal fibroblasts HDF cells was also evaluated. The new heteroleptic complexes were more cytotoxic on T. cruzi and chemoresistant prostate PC3 cells than the benchmark drugs nifurtimox and cisplatin. The compounds also showed a high level of cellular internalization by the OVCAR3 cells and, in particular, those containing the dppe phosphane, showed activation of the cell death mechanism via apoptosis. On the other hand, the production of ROS induced by these complexes was not evident.© 2023 Wiley-VCH GmbH.