化疗是晚期和转移性肿瘤最常用的治疗方法之一。顺铂被认为是固体肿瘤主要的一线化疗药物之一。然而，癌症患者对顺铂的耐药率很高。多药耐药作为癌症患者的主要治疗挑战之一，涉及到各种细胞过程，如药物外泄、DNA修复和自噬。自噬是一种细胞机制，可以保护肿瘤细胞免受化疗药物的伤害。因此，自噬调节因子可以增加或减少肿瘤细胞对化疗的反应。微小RNA在正常和肿瘤细胞中调节自噬的作用至关重要。因此，在本综述中，我们讨论了miRNA在调节自噬中通过对顺铂反应的作用。据报道，miRNA主要通过抑制自噬增加肿瘤细胞的顺铂敏感性。PI3K / AKT信号通路和自噬相关基因（ATGs）是miRNA在调节自噬介导的肿瘤细胞对顺铂反应中的主要靶标。本综述可作为引入miRNA作为有效的治疗选择以增加肿瘤细胞的自噬介导顺铂敏感性的有效步骤。©2023年。作者。

Chemotherapy is one of the most common therapeutic methods in advanced and metastatic tumors. Cisplatin (CDDP) is considered as one of the main first-line chemotherapy drugs in solid tumors. However, there is a high rate of CDDP resistance in cancer patients. Multi-drug resistance (MDR) as one of the main therapeutic challenges in cancer patients is associated with various cellular processes such as drug efflux, DNA repair, and autophagy. Autophagy is a cellular mechanism that protects the tumor cells toward the chemotherapeutic drugs. Therefore, autophagy regulatory factors can increase or decrease the chemotherapy response in tumor cells. MicroRNAs (miRNAs) have a pivotal role in regulation of autophagy in normal and tumor cells. Therefore, in the present review, we discussed the role of miRNAs in CDDP response through the regulation of autophagy. It has been reported that miRNAs mainly increased the CDDP sensitivity in tumor cells by inhibition of autophagy. PI3K/AKT signaling pathway and autophagy-related genes (ATGs) were the main targets of miRNAs in the regulation of autophagy-mediated CDDP response in tumor cells. This review can be an effective step to introduce the miRNAs as efficient therapeutic options to increase autophagy-mediated CDDP sensitivity in tumor cells.© 2023. The Author(s).