虽然围绕恶性肿瘤患者所面临的污名、焦虑、抑郁和生活质量(QoL)方面开展了大量工作，但很少有研究去探究它们之间的关联。本研究探讨了污名、焦虑、抑郁和疾病不确定性对前列腺癌患者生活质量的影响。一项横断面研究在浙江大学医学院附属第一医院对263名被诊断为前列腺癌的患者进行了关于污名、焦虑、抑郁、生活质量和疾病不确定性的调查。主要的研究变量通过结构方程建模进行分析。焦虑和抑郁与生活质量显著负相关 (标准化回归系数 β=-0.312, 标准误差 S.E.=0.478, p<0.05)，这意味着报告更高焦虑程度的参与者生活质量会下降。污名与焦虑和抑郁(β=0.135, S.E.=0.203, p<0.001)以及疾病不确定性(β=0.126, S.E.=2.194, p<0.05)呈正相关。污名直接影响生活质量 (β=-0.209, S.E.=1.655, p<0.001)，但在第三变量(总体焦虑和抑郁)存在时，直接影响会减弱，因为间接影响会通过总体焦虑和抑郁这一变量出现，间接影响的大小为 -0.054。污名影响着焦虑和抑郁、疾病不确定性和生活质量等心理健康方面。医疗保健专业人员可以帮助患者缓解焦虑、抑郁和不确定的感觉，以改善生活质量。©2023. 作者。

Although much work has been carried out on stigma, anxiety and depression, and quality of life(QoL) in cancer patients, far less work has been done to examine their associations. This study explores the effects of stigma, anxiety and depression, and uncertainty in illness on QoL in prostate cancer patients.A cross-sectional study surveyed levels of stigma, anxiety and depression, QoL, and uncertainty in illness in 263 people diagnosed with prostate cancer from the First Affiliated Hospital, Zhejiang University School of Medicine. The main study variables were analyzed by structural equation modeling.Anxiety and depression were significantly negatively related to QoL, with a standardized regression coefficient (β=-0.312, S.E. =0.478, p < 0.05), which means that participants reporting higher levels of anxiety reported decreased levels of QoL. Stigma was positively related to anxiety and depression (β = 0.135, S.E. =0.203, p < 0.001) and uncertainty in illness (β = 0.126, S.E. =2.194, p < 0.05). Stigma has direct effects on QoL (β=-0.209, S.E. =1.655, p < 0.001), but in the presence of a third variable (anxiety and depression overall), direct effects are reduced, as indirect effects emerge through the variable anxiety and depression overall, with an indirect effect size of - 0.054.Stigma impacts mental health, such as anxiety and depression, uncertainty in illness, and QoL. Health care professionals may help patients alleviate feelings of anxiety, depression, and uncertainty in illness to improve QoL outcomes.© 2023. The Author(s).