研究动态
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对于臭茉莉(Paederia foetida Linn.)的药理靶点和生物学机制的研究:一种非常宝贵的传统药用植物。

A delve into the pharmacological targets and biological mechanisms of Paederia foetida Linn.: a rather invaluable traditional medicinal plant.

发表日期:2023 Apr 26
作者: Mrinal Kashyap Sarma, Dipankar Saha, Bhrigu Kumar Das, Trishna Das, Shavkatjon Azizov, Deepak Kumar
来源: ANTIOXIDANTS & REDOX SIGNALING

摘要:

草药或植物药物的开发被认为在探索新的对抗药物方面发挥着重要的作用,近年来引起了广泛的关注。臭茉莉是一种在传统和民间医学中使用的草药。自古以来,该草药的几个部位都被当地人用作天然治疗剂治疗多种疾病。事实上,臭茉莉具有抗糖尿病、降脂、抗氧化、肾脏保护、抗炎、镇痛、止咳、溶栓、抗腹泻、镇静抗焦虑、抗溃疡、肝保护、驱虫和止泻活性。此外,越来越多的证据显示它的多种活性成分对癌症、炎症性疾病、伤口愈合和精子生成也很有效。这些研究揭示了可能的药理靶点,并试图建立这些药理效应的作用机制。这些发现突显了这种草药的重要性,需要进一步研究和探索新的对抗药物,以确定其在保健中的应用前要先建立作用机制。臭茉莉的药理活性及其作用机制。©2023.作者和Springer-Verlag GmbH Germany,Springer Nature部分的独家许可。
Drug development from herbal medicines or botanical sources is believed to have a prominent role in the exploration of novel counteractive drugs that has sparked much interest in recent times. Paederia foetida is one such medicinal plant used in both traditional and folkloric medicine. Several parts of the herb are locally utilised as a natural curative agent for several ailments since time immemorial. Paederia foetida indeed possesses anti-diabetic, anti-hyperlipidaemic, antioxidant, nephro-protective, anti-inflammatory, antinociceptive, antitussive, thrombolytic, anti-diarrhoeal, sedative-anxiolytic, anti-ulcer, hepatoprotective activity, anthelmintic and anti-diarrhoeal activity. Furthermore, growing evidence shows many of its active constituents to be effective in cancer, inflammatory diseases, wound healing and spermatogenesis as well. These investigations shed light on possible pharmacological targets and attempts to establish a mechanism of action for these pharmacological effects. These findings contrast the significance of this medicinal plant for further research and for the exploration of novel counteractive drugs to establish a mechanism of action before being employed to healthcare. Pharmacological activities of Paederia foetida and their mechanism of action.© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.