男性特定的生殖障碍和癌症在近年来急剧增加，成为重要的公共卫生问题。前列腺癌(Prostate cancer, PC)是男性最常见的诊断癌症之一，也是导致癌症相关死亡的主要原因之一。虽然引起这种疾病的确切基础过程尚未被确定，但基因和表观遗传修饰都对PC的发展和进展做出了贡献。男性不育症也是一个复杂且不太被理解的现象，被认为会影响相当一部分男性人口。染色体异常、DNA修复系统受损和Y染色体改变等是一些提出的解释。越来越多的人认为不育症与PC之间存在联系。不育症与PC之间的联系很大程度上可能是由于共同的基因缺陷。本文概述了PC和精子发生异常的情况。这项研究还探讨了男性不育症和PC之间的联系，并揭示了引起这种关联的潜在原因、风险因素和生物机制。©2023年。作者授权Springer Science+ Business Media，LLC独家许可使用，属于Springer Nature的一部分。

Male-specific reproductive disorders and cancers have increased intensely in recent years, making them a significant public health problem. Prostate cancer (PC) is the most often diagnosed cancer in men and is one of the leading causes of cancer-related mortality. Both genetic and epigenetic modifications contribute to the development and progression of PC, even though the exact underlying processes causing this disease have yet to be identified. Male infertility is also a complex and poorly understood phenomenon believed to afflict a significant portion of the male population. Chromosomal abnormalities, compromised DNA repair systems, and Y chromosome alterations are just a few of the proposed explanations. It is becoming widely accepted that infertility shares a link with PC. Much of the link between infertility and PC is probably attributable to common genetic defects. This article provides an overview of PC and spermatogenic abnormalities. This study also investigates the link between male infertility and PC and uncovers the underlying reasons, risk factors, and biological mechanisms contributing to this association.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.