Intraosseous hibernomas是罕见的肿瘤，具有未知病因的褐色脂肪细胞分化，在文献中仅记录了38例。我们试图进一步描述这些肿瘤的临床病理、影像和分子特征。共发现18例，其中8例女性和10例男性（中位年龄=65岁，范围=7-75）。11名患者的影像监测/分期指标，13名患者有转移的临床疑虑。涉及锁骨骨（7）、骶骨（5）、移动脊柱（4）、肱骨（1）和股骨（1）。中位肿瘤大小为1.5厘米（范围=0.8-3.8）。肿瘤呈硬化性（11例）、混合硬化性和溶骨性（4例）或隐匿性（1例）。在显微镜下，肿瘤由大的多角形细胞组成，具有明显的细胞膜、细微的空泡质、中心或副中心的小至极低的细胞核和明显的回弧。观察到了围绕梁骨生长的情况。肿瘤细胞对S100蛋白（15/15）和脂肪酸亲性蛋白（5/5）免疫反应，而对角蛋白AE1/AE3(/PCK26)（14/0）和brachyury（2/0）阴性。在四个病例上进行的染色体微阵列分析没有显示全基因组或AIP和MEN1位点11q上的临床意义的拷贝数变异。在我们所知的最大系列中对18例内骨髓核脂肪瘤进行分析，揭示出这些肿瘤最常在老年人的脊柱和骨盆部位检测到。肿瘤通常较小、硬化性，经常被偶然发现，并可能引起转移的担忧。这些肿瘤是否与软组织的核脂肪瘤有关尚不确定。©2023 John Wiley＆Sons Ltd.

Intraosseous hibernomas are rarely reported tumours with brown adipocytic differentiation of unknown aetiology, with only 38 cases documented in the literature. We sought to further characterise the clinicopathologic, imaging and molecular features of these tumours.Eighteen cases were identified occurring in eight females and 10 males (median age = 65 years, range = 7-75). Imaging indication was cancer surveillance/staging in 11 patients and clinical concern for a metastasis was raised in 13 patients. The innominate bone (7), sacrum (5), mobile spine (4), humerus (1) and femur (1) were involved. Median tumour size was 1.5 cm (range = 0.8-3.8). Tumours were sclerotic (11), mixed sclerotic and lytic (4) or occult (1). Microscopically, tumours were composed of large polygonal cells with distinct cell membranes, finely vacuolated cytoplasm, central or paracentral small bland nuclei with prominent scalloping. Growth around trabecular bone was observed. Tumour cells were immunoreactive for S100 protein (15/15) and adipophilin (5/5), while negative for keratin AE1/AE3(/PCK26) (0/14) and brachyury (0/2). Chromosomal microarray analysis, performed on four cases, did not show clinically significant copy number variation across the genome or on 11q, the site of AIP and MEN1.Analysis of 18 cases of intraosseous hibernoma, to our knowledge, the largest series to date, revealed that these tumours are most often detected in the spine and pelvis of older adults. Tumours were generally small, sclerotic and frequently found incidentally and can raise concern for metastasis. Whether or not these tumours are related to soft tissue hibernomas is uncertain.© 2023 John Wiley & Sons Ltd.