口腔鳞状细胞癌（OSCC）在我们的社会中逐渐增多。不幸的是，大多数患者在晚期被诊断出来，这意味着治疗更加困难，预后更差。这篇系统综述的目的是评估细胞因子IL-6，IL-8和TNF-α是否是潜在的唾液生物标志物，可用于早期肿瘤诊断。在三个数据库（Pubmed、Scopus和Web of Science）中进行了电子检索。我们使用了以下关键词：“唾液细胞因子”，“口腔鳞状细胞癌”，“生物标志物”，“诊断”，并结合了布尔运算符“AND”和“OR”。共找到128篇出版物，最终在综述中包括了23篇文章，元分析中包括15篇文章。观察到大多数OSCC患者的唾液浓度比对照组（CL）和癌前病变（OPML）组高。还观察到不同的癌前病变在细胞因子的唾液浓度方面没有统计学显着差异，而在不同的TNM分期之间却有差异。元分析显示，IL-6、IL-8和TNF-α的浓度差异在CL组和OSCC组之间以及CL组和OPML组之间是有统计学意义的。有足够的证据表明，IL-6、IL-8和TNF-α是早期诊断和预后评估OSCC有用的唾液细胞因子。虽然未来的研究有必要建立这些生物标志物更可靠的可靠性，从而能够开发出有效的诊断测试。

Oral squamous cell carcinoma (OSCC) is gradually increasing its incidence in our society. Unfortunately, this entity is diagnosed at an advanced stage in most patients, a fact that implies greater difficulty in its treatment and a worse prognosis. This systematic review aims to assess whether the cytokines IL-6, IL-8 and TNF-α are potential salivary biomarkers that allow early diagnosis of cancer.An electronic search was performed in three databases (Pubmed, Scopus and Web of Science). We used the following keywords: "salivary cytokines", "saliva cytokines", "salivary interleukins", "biomarkers", "oral squamous cell carcinoma" and "diagnosis", combined with the Boolean operators "AND" and "OR".128 publications were found and finally 23 articles were included in the review and 15 in the meta-analysis. It has been observed that the majority of OSCC patients express higher salivary concentrations of IL-6, IL-8 and TNF-α compared to the control (CL) and premalignant lesion (OPML) groups. It has also been observed that the different premalignant lesions do not have statistically significant differences in the salivary concentration of the cytokines, and on the other hand, differences have been observed between the different TNM stages. The meta-analysis has shown that the difference in concentration of IL-6, IL-8 and TNF-α is statistically significant between the CL group and the OSCC, and also between the CL group and OPML.There is sufficient evidence to affirm that IL-6, IL-8 and TNF-α are useful salivary cytokines in the early diagnosis and prognosis of OSCC. Although future studies are necessary to establish greater reliability of these biomarkers and thus be able to develop a valid diagnostic test.