RING finger protein 26（RNF26）在决定恶性肿瘤生长中起着重要作用，然而它在胰腺癌（PC）中的作用尚未报道。本研究旨在研究RNF26在PC细胞中的作用。应用基因表达谱交互分析工具研究RNF26在恶性肿瘤中的作用。采用体外或体内细胞增殖实验来研究RNF26在PC中的作用。采用蛋白质相互作用网络分析来查找RNF26的结合伙伴。采用Western blot来揭示RNF26是否促进了PC细胞中RNA结合蛋白38（RBM38）的降解。基因表达谱交互分析工具显示RNF26在PC中过表达。抑制RNF26表达可以减少PC细胞的生长，而过表达RNF26则增加了PC的增殖。此外，我们证明RNF26通过降解RBM38促进PC细胞的增殖。在PC中，RNF26异常增加，且上调的RNF26与恶性预后有关。RNF26通过诱导RBM38降解来促进PC细胞的增殖。我们鉴定了一个新的RNF26-RBM28轴参与PC的进展。版权所有©2023 Wolters Kluwer Health，Inc.，保留所有权利。

RING finger protein 26 (RNF26) plays an essential role in determining malignant tumor growth, whereas the role of which in pancreatic cancer (PC) has not been reported. This study aimed to investigate the role of RNF26 in PC cells.The Gene Expression Profiling Interactive Analysis was applied to study the role of RNF26 in malignant tumors. The in vitro or in vivo cell proliferation assays were used to investigate the role of RNF26 on the PC. The protein-protein interaction network analysis was used to search the binding partner of RNF26. The Western blot was used to reveal whether RNF26 promoted RNA binding motif protein-38 (RBM38) degradation in PC cells.The Gene Expression Profiling Interactive Analysis tool showed that RNF26 was overexpressed in PC. Repressing RNF26 expression decreased PC cells growth, but overexpression of RNF26 increased PC proliferation. Furthermore, we demonstrated RNF26 degraded RBM38 to promote PC cell proliferation.RNF26 was abnormally increased in PC, and upregulated RNF26 was correlated with a poor prognosis. RNF26 enhanced PC proliferation by inducing RBM38 degradation. We identified a novel RNF26-RBM28 axis involved in the progression of PC.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.