开发超灵敏的生物传感器用于癌症检测和治疗监测是至关重要的。在传感平台的开发中，金属有机框架（MOFs）因其潜在的多孔结晶纳米结构，受到了广泛关注。核壳MOF纳米粒子（NPs）展示了不同的多样性、复杂性、生物功能性，以及重要的电化学（EC）性质和潜在的与适配体的生物亲和性。因此，开发的基于核壳MOF的适配体传感器作为高度敏感的平台用于感应具有极低检测限制（LOD）的癌症生物标记物。本文旨在概述不同的策略，以改善MOF纳米结构的选择性、灵敏度和信号强度。然后，适配体及其修饰的核壳MOFs进行了回顾，以解决它们在生物传感平台中的功能化和应用。此外，还讨论了核壳MOF辅助的EC适配体传感器在检测多种肿瘤抗原，如前列腺特异抗原（PSA）、糖类抗原15-3（CA15-3）、癌胚抗原（CEA）、人表皮生长因子受体-2（HER2）、癌抗原125（CA-125）、细胞角蛋白19碎片（CYFRA21-1）及其他肿瘤标志物方面的应用。总之，本文回顾了基于核壳MOFs的EC适配体传感器的发展，朝着检测特定癌症生物标志物的潜在生物传感平台的进展。©2023作者。

It is essential to develop ultrasensitive biosensors for cancer detection and treatment monitoring. In the development of sensing platforms, metal-organic frameworks (MOFs) have received considerable attention as potential porous crystalline nanostructures. Core-shell MOF nanoparticles (NPs) have shown different diversities, complexities, and biological functionalities, as well as significant electrochemical (EC) properties and potential bio-affinity to aptamers. As a result, the developed core-shell MOF-based aptasensors serve as highly sensitive platforms for sensing cancer biomarkers with an extremely low limit of detection (LOD). This paper aimed to provide an overview of different strategies for improving selectivity, sensitivity, and signal strength of MOF nanostructures. Then, aptamers and aptamers-modified core-shell MOFs were reviewed to address their functionalization and application in biosensing platforms. Additionally, the application of core-shell MOF-assisted EC aptasensors for detection of several tumor antigens such as prostate-specific antigen (PSA), carbohydrate antigen 15-3 (CA15-3), carcinoembryonic antigen (CEA), human epidermal growth factor receptor-2 (HER2), cancer antigen 125 (CA-125), cytokeratin 19 fragment (CYFRA21-1), and other tumor markers were discussed. In conclusion, the present article reviews the advancement of potential biosensing platforms toward the detection of specific cancer biomarkers through the development of core-shell MOFs-based EC aptasensors.© 2023. The Author(s).