通过ctDNA检测到的早期转移性HPV相关喉咽腺鳞状癌。
HPV-associated oropharyngeal Adenosquamous carcinoma with early metastatic disease detected by ctDNA.
发表日期：2023 Oct
作者：
Samantha Newman, J Harrison Cowart, Nivin Omar, Elizabeth Martin, J Kenneth Byrd
来源：
ORAL ONCOLOGY
摘要：
腺鳞癌是一种罕见而侵袭性的鳞状细胞癌变体，可能是在口咽部由人乳头状瘤病毒（HPV）驱动。尽管据报道其行为与与HPV相关的鳞状细胞癌类似，但该疾病的文献非常有限。我们报道了一例扁桃体早期T和N期的HPV +腺鳞癌，即使仅存在微小的淋巴结负担，在手术和辅助治疗后立即发生转移。循环肿瘤DNA（ctDNA）在早期识别和挽救转移性疾病中起到了重要作用，通过辐射治疗实现。版权所有©2023 Elsevier Ltd.。保留所有权利。
Adenosquamous Carcinoma is a rare, aggresssive variant of squamous cell carcinoma that may HPV-driven in the oropharynx. Although it is reported to behave similar to HPV-related squamous cell carcinoma, the literature is very limited for this disease. We present a case of early T and N stage HPV + adenosquamous carcinoma of the tonsil that metastasized immediately following surgery and adjuvant therapy despite only having microscopic nodal burden. Circulating tumor DNA (ctDNA) was instrumental in recognizing and salvaging metastatic disease early with radiation.Copyright © 2023 Elsevier Ltd. All rights reserved.