κ-增强子激活的B细胞的核因子（NF-κB）信号通路在脊椎动物中起到重要作用，对于人类疾病的发展，如与炎症相关的疾病和肿瘤发生具有重要影响。血管新生是指从已有的毛细血管和后毛细静脉中形成新的毛细血管。保持正常的血管新生和有效的血管功能是维持器官组织功能稳定性的前提条件，而异常的血管新生往往导致多种疾病。在病理条件下，已经提出了在血管分化、增殖、凋亡和肿瘤发生过程中，NK-κB信号分子通过调控多个靶基因的转录起到重要作用。许多NF-κB抑制剂正在临床试验中用于癌症治疗，本文总结了它们对血管新生的影响。本综述综合了NF-κB信号在各种血管新生性疾病，尤其是肿瘤中的作用，并探讨了NF-κB是否可以作为攻击靶点或激活介质来抑制肿瘤血管新生。

The nuclear factor of κ-light chain of enhancer-activated B cells (NF-κB) signaling pathway, which is conserved in invertebrates, plays a significant role in human diseases such as inflammation-related diseases and carcinogenesis. Angiogenesis refers to the growth of new capillary vessels derived from already existing capillaries and postcapillary venules. Maintaining normal angiogenesis and effective vascular function is a prerequisite for the stability of organ tissue function, and abnormal angiogenesis often leads to a variety of diseases. It has been suggested that NK-κB signalling molecules under pathological conditions play an important role in vascular differentiation, proliferation, apoptosis and tumourigenesis by regulating the transcription of multiple target genes. Many NF-κB inhibitors are being tested in clinical trials for cancer treatment and their effect on angiogenesis is summarised. In this review, we will summarise the role of NF-κB signalling in various neovascular diseases, especially in tumours, and explore whether NF-κB can be used as an attack target or activation medium to inhibit tumour angiogenesis.