一些唾液腺肿瘤很少报告有梗死的情况。在本研究中，我们报道了唾液基底细胞腺瘤中首例发生梗死的案例。一名62岁的男性患者出现左腮腺区的肿胀。组织病理学检查显示广泛的中央坏死，周围有一圈具有典型基底细胞腺瘤组织学特征的活性肿瘤组织。在肿瘤中检测到核内β-连环蛋白表达和CTNNB1 p.I35T（c.104 T > C）突变。确诊为具有中央坏死的基底细胞腺瘤，并且术后恢复顺利。此外，我们对唾液腺基底细胞肿瘤中CTNNB1 I35T突变进行了文献回顾。对唾液腺肿瘤的鉴别诊断可能发生梗死的可能性以及基底细胞腺瘤中独特突变的高频率的认识将有助于临床实践。版权所有 © 2023 Elsevier Ltd. 保留所有权利。

Infarction has rarely been reported in some types of salivary gland tumors. In this study, we present the first case of infarction occurring in salivary basal cell adenoma. A 62-year-old male presented with swelling in the left parotid region. Histopathological examination revealed extensive central necrosis surrounded by a rim of viable tumor tissue showing the typical histology of basal cell adenoma. Nuclear β-catenin expression and the CTNNB1 p.I35T (c.104 T > C) mutation were identified in the tumor. A diagnosis of basal cell adenoma with central necrosis was made, and the postoperative period was uneventful. In addition, we review the literature on CTNNB1 I35T mutations in basal cell neoplasms of the salivary glands. Awareness of the possible occurrence of infarction and the high frequency of the unique mutation in basal cell adenoma may help in the differential diagnosis of salivary gland tumors.Copyright © 2023 Elsevier Ltd. All rights reserved.