胰腺癌（PC）是一种最恶性的消化系统肿瘤，其特点是预后不佳。接受化疗的PC患者可能会忍受巨大的生理和心理痛苦，对精神幸福感和生活质量产生负面影响。本研究旨在调查PC化疗患者的精神幸福感和生活质量状况，识别和分析影响因素，并制定可行的精神护理计划，为临床医务人员在促进PC化疗患者的精神幸福感和生活质量方面提供参考。研究团队进行了前瞻性调查。本研究在中国重庆陆军军医大学第二附属医院进行。参与者是在2020年11月至2022年4月期间在该医院接受胰腺癌（PC）化疗的120名患者。研究团队使用便捷抽样法选择参与者。结果评估包括：（1）自设计问卷，用于确定参与者的人口特征和临床特征，以及（2）慢性疾病治疗功能评估-精神幸福感量表（FACIT-Sp）。研究团队使用FACIT-Sp的两个子量表，FACT-G和FACIT-Sp-12，分别评估参与者的生活质量和精神幸福感。参与者的精神幸福感和生活质量的总分分别为26.2 ± 5.39和65.44 ± 17.1。精神幸福感与生活质量呈正相关（P < .001）。根据多元线性回归分析，影响精神幸福感的主要因素是年龄（P < .01）、教育水平（P < .001）、家庭人均平均月收入（P < .001）、复发（P < .001）和疼痛（P < .05）。影响生活质量的主要因素是年龄（P = .008）、教育水平（P < .001）、家庭人均平均月收入（P < .001）、复发（P < .001）和疼痛（P < .01）。接受胰腺癌化疗的患者的精神幸福感水平属于低至中等水平，生活质量水平为中等水平。不利的因素包括：（1）处于中年，（2）教育水平低，（3）家庭收入低，（4）疾病复发，（5）经历中度至重度疼痛。医务人员应提供额外关心和支持，保护这些患者的精神幸福感，最终改善其生活质量。

Pancreatic cancer (PC) is one of the most malignant digestive cancers, characterized by a poor prognosis. PC patients receiving chemotherapy can endure immense physical and psychological pain, negatively impacting spiritual well-being and QoL.The study intended to investigate PC patients' statuses regarding spiritual well-being and QoL, to identify and analyze the influencing factors, and to develop feasible spiritual-care plans, which could provide a reference for clinicians in promoting the spiritual well-being and QoL of PC chemotherapy patients.The research team performed a prospective survey.The study took place at the Second Affiliated Hospital of the Army Medical University in Chongqing, China.Participants were 120 patients who underwent chemotherapy for pancreatic cancer (PC) at the hospital between November 2020 and April 2022. The research team selected participants using convenience sampling.The outcome measures included: (1) a self-designed questionnaire to identify participants' demographic and clinical characteristics and (2) the Functional Assessment of Chronic Illness Therapy-Spiritual Well-being Scales (FACIT-Sp). The research team used the FACIT-Sp's two subscales, FACT-G and the FACIT-Sp-12, to evaluate participants' quality of life (QoL) and spiritual well-being, respectively.The total scores for participants' spiritual well-being and QoL were 26.2 ± 5.39 and 65.44 ± 17.1, respectively. Spiritual well-being was positively correlated with the QoL (P < .001). According to the multiple linear regression analysis, the main factors influencing spiritual well-being were age (P < .01), education level (P < .001), average monthly income per capita of the family (P < .001), recurrence (P < .001), and pain (P < .05). The main factors influencing QoL were age (P = .008), education level (P < .001), average monthly income per capita of the family (P < .001), recurrence (P < .001), and pain (P < .01).Patients who undergo chemotherapy for PC experience a low-to-medium level of spiritual well-being and a medium level of QoL. The detrimental factors include: (1) being middle-aged, (2) having a low education level, (3) having a low family income, (4) suffering a recurrence of the disease, and (5) experiencing moderate-to-severe pain. Medical practitioners should provide extra care and support to protect the spiritual well-being of these patients and ultimately improve their QoL.