细胞可塑性代表着细胞被重新编程和改变命运和身份的能力，使其能够在损伤后恢复稳态和组织再生。细胞可塑性还会导致病理条件，如癌症，使细胞在不同细胞状态之间转换，获得新的表型和功能特征，从而促进肿瘤的发生、发展、转移和对治疗的耐受性。本文将回顾推动细胞可塑性的内在和外在机制，促进肿瘤生长、增殖以及转移和耐药性。最后，我们将讨论如何利用细胞可塑性来进行抗癌治疗。© 2023. Springer Nature America, Inc.

Cell plasticity represents the ability of cells to be reprogrammed and to change their fate and identity, enabling homeostasis restoration and tissue regeneration following damage. Cell plasticity also contributes to pathological conditions, such as cancer, enabling cells to acquire new phenotypic and functional features by transiting across distinct cell states that contribute to tumor initiation, progression, metastasis and resistance to therapy. Here, we review the intrinsic and extrinsic mechanisms driving cell plasticity that promote tumor growth and proliferation as well as metastasis and drug tolerance. Finally, we discuss how cell plasticity could be exploited for anti-cancer therapy.© 2023. Springer Nature America, Inc.