目标：本研究利用文献计量方法评估2014年至2022年全球与体积调节型阴离子通道（VRAC）相关的科研产出及研究热点。方法：从Web of Science获取了2014年至2022年与VRAC相关的研究。我们使用网络可视化工具VOSviewer对国家、机构和作者之间的合作进行网络分析。此外，我们对期刊共引用、文献引用和关键词共现进行分析。此外，我们还使用CiteSpace（6.1.R6高级版）对具有最强突发引用的关键词和共被引用文献进行分析。结果：最终分析包括了2014年至2022年共278篇相关文章和综述。美国成为该领域的主要贡献国家，而哥本哈根大学成为最重要的机构。发表最多文章并被引用最多的作者是Thomas J. Jentsch。在被引用的参考文献中，Voss等人在《科学》杂志（2014年）发表的文章因其将LRRC8异构体确定为体积调节型阴离子通道VRAC的关键组成部分而受到重视。《Pflügers Archiv European Journal of Physiology》和《Journal of Physiology-London》是最具相关文章和引用数量的期刊。通过对关键词共现的分析，发现VRAC参与了包括细胞生长、迁移、凋亡、肿胀和肌肉生成在内的多种生理过程，以及氯离子、牛磺酸、谷氨酸和ATP等阴离子和有机渗透物的运输。VRAC还与TMEM16A、TMEM16F、Pannexin和CFTR等相关离子通道以及癫痫、白质脑病、动脉粥样硬化、高血压、脑水肿、中风以及各种癌症如胃癌、胶质母细胞瘤和肝细胞癌等疾病有关。此外，VRAC通过调节铂类药物和替莫唑胺的摄取参与抗肿瘤药物耐药性的研究。此外，VRAC已在DCPIB和类黄酮等药理学研究中得到研究。结论：文献计量分析的目的是为VRAC的研究提供全面的视角。VRAC成为了一个越来越受关注的课题，并且我们的分析表明它仍然是一个重要的领域。本研究为VRAC通道的研究提供了深入见解，并可能引导研究人员确定未来研究的新方向。版权所有©2023年刘、李、王、Stauber和赵

Objective: In this study, we utilized bibliometric methods to assess the worldwide scientific output and identify hotspots related to the research on the volume-regulated anion channel (VRAC) from 2014 to 2022. Methods: From Web of Science, we obtained studies related to VRAC published from 2014 to 2022. To analyzed the data, we utilized VOSviewer, a tool for visualizing network, to create networks based on the collaboration between countries, institutions, and authors. Additionally, we performed an analysis of journal co-citation, document citation, and co-occurrence of keywords. Furthermore, we employed CiteSpace (6.1. R6 Advanced) to analyzed keywords and co-cited references with the strongest burst. Results: The final analysis included a total of 278 related articles and reviews, covering the period from 2014 to 2022. The United States emerged as the leading country contributing to this field, while the University of Copenhagen stood out as the most prominent institution. The author with most publications and most citations was Thomas J. Jentsch. Among the cited references, the article by Voss et al. published in Science (2014) gained significant attention for its identification of LRRC8 heteromers as a crucial component of the volume-regulated anion channel VRAC. Pflügers Archiv European Journal of Physiology and Journal of Physiology-London were the leading journals in terms of the quantity of associated articles and citations. Through the analysis of keyword co-occurrence, it was discovered that VRAC is involved in various physiological processes including cell growth, migration, apoptosis, swelling, and myogenesis, as well as anion and organic osmolyte transport including chloride, taurine, glutamate and ATP. VRAC is also associated with related ion channels such as TMEM16A, TMEM16F, pannexin, and CFTR, and associated with various diseases including epilepsy, leukodystrophy, atherosclerosis, hypertension, cerebral edema, stroke, and different types of cancer including gastric cancer, glioblastoma and hepatocellular carcinoma. Furthermore, VRAC is involved in anti-tumor drug resistance by regulating the uptake of platinum-based drugs and temozolomide. Additionally, VRAC has been studied in the context of pharmacology involving DCPIB and flavonoids. Conclusion: The aim of this bibliometric analysis is to provide an overall perspective for research on VRAC. VRAC has become a topic of increasing interest, and our analysis shows that it continues to be a prominent area. This study offers insights into the investigation of VRAC channel and may guide researchers in identifying new directions for future research.Copyright © 2023 Liu, Li, Wang, Stauber and Zhao.