酒精引起的肝损伤对人类健康构成了重大威胁。已经证实益生菌可以预防和治疗酒精引起的肝损伤。本研究调查了双歧杆菌乳杆菌TY-S01在小鼠酒精引起的肝损伤中的预防效果。TY-S01预处理能有效保护小鼠不受酒精引起的肝损伤影响，维持血清中丙氨酸转氨酶、天门冬酰胺酶、碱性磷酸酶、甘油三酯和高密度脂蛋白胆固醇水平，并维持肝组织中炎症因子肿瘤坏死因子-α、白细胞介素-6和白细胞介素-1β的水平。此外，TY-S01还能维持血清内毒素水平，维持肠道紧密连接蛋白zonula occluden-1、occludin，claudin-1和claudin-3的mRNA表达水平，并能预防酒精性肝损伤小鼠肠道微生物失调。斯皮尔曼相关性分析显示血清指标、炎症因子和肠道微生物之间存在明显相关性。总之，TY-S01通过保护肠道屏障完整性和维持肠道微生物平衡来减轻酒精引起的肝损伤。© 2023 The Authors.

Alcohol-induced liver injury poses a significant threat to human health. Probiotics have been proven to prevent and treat alcohol-induced liver injury. In this study, the preventive effect of Bifidobacterium lactis TY-S01 on alcohol-induced liver injury in mice was investigated. TY-S01 pretreatment effectively protected mice against alcohol-induced liver injury by preserving the levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, triglyceride and high-density lipoprotein-cholesterol in serum and maintaining the levels of the inflammatory cytokines tumor necrosis factor-α, interleukin-6 and interleukin-1β in liver tissue. Additionally, TY-S01 could maintain the endotoxin levels in serum, maintain the mRNA expression levels of zonula occluden-1, occludin, claudin-1 and claudin-3 in the gut, and prevent gut microbiota dysbiosis in mice with alcoholic liver injury. Spearman's correlation analysis revealed that there was a clear correlation among serum indicators, inflammatory cytokines and gut microbiota. In conclusion, TY-S01 attenuates alcohol-induced liver injury by protecting the integrity of the intestinal barrier and maintaining the balance of the gut microbiota.© 2023 The Authors.