本研究评估了术前血浆D-二聚体水平与胰腺导管腺癌根治术患者的总生存期和无复发生存期之间的关系。收集了573例胰腺导管腺癌患者的术前血浆D-二聚体水平。使用单变量和多变量Cox风险模型来确定与总生存期和无复发生存期相关的独立变量。采用Kaplan-Meier方法评估总生存期和无复发生存期，并使用Log-rank检验分析生存曲线之间的差异。连续变量以$\overline{x}\pm s$形式表示，采用T检验进行参数分析。分类变量采用卡方检验或Fisher精确检验进行分析。基于整个研究的分析结果显示，血浆D-二聚体水平升高的患者具有年龄较大的趋势（58.69 ± 8.32岁 vs. 63.05 ± 8.44岁，P < 0.001），肿瘤大小≥4 cm（P = 0.006），T分期（P = 0.024），N分期（P = 0.041），肿瘤、淋巴结和转移（TNM）分期（P = 0.029），以及术后并发症（P = 0.042）的发生更为常见。此外，根据Cox多变量分析结果，术前血浆D-二聚体水平的升高是总生存期的独立预后因子（风险比（HR）：1.430，95%置信区间（CI）（1.163-1.759），P = 0.001），也是无复发生存期的独立预后因子（HR：1.236，95% CI（1.018-1.500），P = 0.032）。在我们的研究中，胰腺导管腺癌术前血浆D-二聚体水平升高可能作为总生存期和无复发生存期的独立预后因子。与血浆D-二聚体水平正常的病人相比，术前血浆D-二聚体水平升高的胰腺导管腺癌病人预后较差；而术前血浆D-二聚体水平升高可能意味着较重的肿瘤负担，并提供有关疾病状态的补充信息。© 版权所有2023。

In this study, the relationship between preoperative plasma D-dimer level and overall survival and recurrence free survival were evaluated in patients with curative resection of pancreatic ductal adenocarcinoma.Preoperative plasma D-dimer level of 573 patients with pancreatic ductal adenocarcinoma were collected. The univariate and multivariate Cox hazard models were used to identify independent variables associated with overall survival and recurrence free survival in this study. The Kaplan-Meier method was used to evaluate overall survival and recurrence free survival, and the differences between survival curves were analyzed using the Log-rank test. Continuous variables were presented as $\overline{x}\pm s$, parametric analysis was performed using t-test. Categorical variables were analyzed by means of the chi-square or Fisher's exact test.Based on the analysis for the whole study, the results showed that patients in the elevated plasma D-dimer levels had a tendency to have an elder mean age (58.69 ± 8.32 years vs. 63.05 ± 8.44 years, P < 0.001), larger tumour size ≥4 cm (P = 0.006), advanced T stage (P = 0.024), N stage (P = 0.041), Tumor, Node and Metastasis (TNM) stage (P = 0.029) and postoperative complications (P = 0.042) was more likely occurred. Besides, according to the results of Cox multivariate analysis, elevated preoperative plasma D-dimer level was an independent prognostic factor not only for overall survival (Hazard Ratio (HR):1.430, 95% Confidence Interval (CI) (1.163-1.759), P = 0.001) but also for recurrence free survival (HR:1.236, 95% CI (1.018-1.500), P = 0.032).In our study, the elevated preoperative plasma D-dimer level may act as an independent prognostic factor for overall survival and recurrence free survival in patients with pancreatic ductal adenocarcinoma after curative resection. Pancreatic ductal adenocarcinoma patients with elevated preoperative plasma D-dimer level had a worse prognosis than those with normal plasma D-dimer level; and the elevated preoperative plasma D-dimer level may imply heavy tumour burden and provide supplementary information regarding disease status.© Crown copyright 2023.