胶质母细胞瘤是现代肿瘤学领域面临的最致命恶性肿瘤之一。虽然过去十年来我们对胶质母细胞瘤生物学的某些方面有了显著提高的理解，但其他方面，如生物活性金属在胶质母细胞瘤进展中的作用，仍然研究不足。铁是地壳中最丰富的过渡金属，由于其参与氧化还原反应的能力，对人体生理学具有复杂作用。当我们研究铁缺乏或铁超载的临床后果时，铁在人体生理学中的重要性是显而易见的。尽管如此，铁在胶质母细胞瘤进展中的作用尚未得到很好的描述。在本文中，我们对现有文献进行回顾和综述，探讨铁在胶质母细胞瘤进展和患者预后中的作用，并对胶质母细胞瘤微环境中主要细胞类型的铁的分子和细胞水平的影响进行调查。考虑到已获批准的铁补充剂和螯合剂的可用性，铁代谢是一个可进取的靶点。提高我们对铁在胶质母细胞瘤生物学中的作用的理解可能为调节铁的方法改善患者预后铺平道路。© 2023 作者(s). 由牛津大学出版社代表神经肿瘤学学会出版。 保留所有权利。 如需许可，请发送电子邮件至：journals.permissions@oup.com。

Glioblastoma is among the deadliest malignancies facing modern oncology. While our understanding of certain aspects of glioblastoma biology has significantly increased over the last decade, other aspects, such as the role of bioactive metals in glioblastoma progression, have remain understudied. Iron is the most abundant transition metal found within the earth's crust and plays an intricate role in human physiology owing to its ability to participate in oxidation-reduction reactions. The importance of iron homeostasis in human physiology is apparent when examining the clinical consequences of iron deficiency or iron overload. Despite this, the role of iron in glioblastoma progression has not been well described. Here we review and synthesize the existing literature examining iron's role in glioblastoma progression and patient outcomes, as well as provide a survey of iron's effects on the major cell types found within the glioblastoma microenvironment at the molecular and cellular level. Iron represents an accessible target given the availability of already approved iron supplements and chelators. Improving our understanding of iron's role in glioblastoma biology may pave the way for iron modulating approaches to improve patient outcomes.© The Author(s) 2023. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.