蛋白酶A解聚素与金属蛋白酶17（ADAM17）在多种疾病的病理生理学中发挥核心作用。ADAM17参与至少80种已知的膜锚蛋白的切割和脱落，进而调控多个细胞内信号通路，从而改变细胞行为。异常表达和/或活化的ADAM17与广泛的自身免疫和炎症性疾病、癌症和心血管疾病相关联。在本综述中，我们综合目前针对ADAM17多样病理生理角色的临床前模型和临床数据，探讨了ADAM17介导的蛋白质脱落机制以及针对这些疾病中ADAM17靶向治疗的潜在治疗意义。本文受版权保护，保留所有权利。

The protease A Disintegrin And Metalloproteinase 17 (ADAM17) plays a central role in the pathophysiology of several diseases. ADAM17 is involved in the cleavage and shedding of at least 80 known membrane-tethered proteins, which subsequently modulate several intracellular signaling pathways, and therefore alter cell behavior. Dysregulated expression and/or activation of ADAM17 has been linked to a wide range of autoimmune and inflammatory diseases, cancer and cardiovascular disease. In this review, we provide an overview of the current state of knowledge from preclinical models and clinical data on the diverse pathophysiological roles of ADAM17, and discuss the mechanisms underlying ADAM17-mediated protein shedding and the potential therapeutic implications of targeting ADAM17 in these diseases.This article is protected by copyright. All rights reserved.