卵巢肿瘤发生的机制之一是由于炎症引起的。肾功能不全与增强的炎症有关，因此我们评估了其与卵巢癌风险的关系。在前瞻性收集的样本中，我们评估了肾功能标志物和C反应蛋白（CRP）与英国生物库中卵巢癌风险的关联。我们使用多变量调整的Cox比例风险模型评估了血清和尿液标志物的四分位数与总体卵巢癌风险以及按组织学分类的关系。我们评估了CRP（≤3.0，>3.0 mg/L）的效应修饰。 在232,908名女性中（从2006年至2020年诊断的1,110例卵巢癌病例），我们观察到估计的肾小球滤过率与卵巢癌风险之间没有关联（Q4 vs. Q1：风险比：1.00，95%的置信区间：0.83，1.22）。钾与子宫内膜样（Q4 vs. Q1：0.33 [0.11,0.98]）和透明细胞（4.74 [1.39,16.16]）肿瘤有关。肾功能不良与CRP >3.0 mg/L的女性卵巢癌风险呈非显著性增加相关（例如，尿酸Q4 vs. Q1：1.23 [0.81,1.86]），但与CRP ≤3.0 mg/L的女性无关（0.83 [0.66,1.05]）。其他关联在CRP类别之间没有变化。 肾功能与卵巢癌风险明确相关。需要进行更大规模的研究以评估可能的组织学特异性关联。鉴于肾功能不良和高CRP的女性卵巢癌风险增加的暗示性趋势，未来的研究还需在患炎症疾病高流行的人群中进行，尤其如此。 本研究首次评估了肾功能标志物与卵巢癌风险的关系。

One of the mechanisms of ovarian tumorigenesis is through inflammation. Kidney dysfunction is associated with increased inflammation; thus we assessed its relationship with ovarian cancer risk.In prospectively collected samples, we evaluated the association of kidney function markers and C reactive protein (CRP) with ovarian cancer risk in the UK Biobank. We used multivariable-adjusted Cox proportional hazards models to evaluate quartiles of serum and urine markers with ovarian cancer risk overall and by histology. We assessed effect modification by CRP (≤3.0, >3.0 mg/L).Among 232,908 women (1,110 ovarian cancer cases diagnosed from 2006-2020), we observed no association between estimated glomerular filtration rate and ovarian cancer risk (Q4 vs. Q1: Hazard Ratio: 1.00, 95% Confidence Intervals: 0.83,1.22). Potassium was associated with endometrioid (Q4 vs. Q1: 0.33 [0.11,0.98]) and clear cell (4.74 [1.39,16.16]) tumors. Poor kidney function was associated with a non-significant increase in ovarian cancer risk among women with CRP >3.0 mg/L (e.g., uric acid Q4 vs. Q1. 1.23 [0.81,1.86]), but not CRP ≤3.0 mg/L (0.83 [0.66,1.05]). Other associations did not vary across CRP categories.Kidney function was not clearly associated with ovarian cancer risk. Larger studies are needed to evaluate possible histology specific associations. Given the suggestive trend for increased ovarian cancer risk in women with poor kidney function and high CRP, future work is needed, particularly in populations with a high prevalence of inflammatory conditions.This study provided the first evaluation of markers of kidney function in relation to ovarian cancer risk.