有机锡(IV)配合物在癌症治疗中的药理活性被广泛认可，但它们的广泛应用受到其水溶性差的限制。因此，碳点，特别是氮掺杂石墨烯量子点(NGQDs)，可能是有效传递有机锡(IV)化合物的有前景的替代品，因为它们具有可观的水溶解度、良好的化学稳定性和非毒性，以及明亮的光致发光性能，使它们成为抗癌治疗领域的理想选择。基于两个有机锡类细胞毒化合物和对苯二甲酸醛缩合物(FBA)，构建了两种不同的多功能纳米体系，并对其进行了全面的表征。随后，对实现的多功能体系的治疗潜力和疗效诊断进行了体外确定。结果表明，NGQDs-FBA-Sn材料对乳腺癌细胞系(MDA-MB-231)具有较高的细胞毒性，对非癌细胞系(肾细胞，HEK293T)的影响较小。此外，由于它们的光学特性，这些碳点能够在细胞质区域进行荧光分子成像，表明其成功被癌细胞摄取，并释放金属药物(NGQDs-FBA-Sn)。© 2023 Wiley-VCH GmbH.

The pharmacological activity of organotin(IV) complexes in cancer therapy is well recognized but their large applicability is hampered by their poor water solubility. Hence, carbon dots, in particular nitrogen-doped graphene quantum dots (NGQDs), may be a promising alternative for the efficient delivery of organotin(IV) compounds as they have a substantial aqueous solubility, a good chemical stability, and non-toxicity as well as a bright photoluminescence that make them ideal for theranostic applications against cancer. Two different multifunctional nanosystems have been synthesized and fully characterized based on two fragments of organotin-based cytotoxic compounds and 4-formylbenzoic acid (FBA), covalently grafted onto the NGQDs surface. Subsequently, an in vitro determination of the therapeutic and theranostic potential of the achieved multifunctional systems was carried out. The results showed a high cytotoxic potential of the NGQDs-FBA-Sn materials against breast cancer cell line (MDA-MB-231) and a lower effect on a non-cancer cell line (kidney cells, HEK293T). Besides, thanks to their optical properties, the dots enabled their fluorescence molecular imaging in the cytoplasmatic region of the cells pointing towards a successful cellular uptake and a release of the metallodrug inside cancer cells (NGQDs-FBA-Sn).© 2023 Wiley-VCH GmbH.