光热疗法（PTT）能以高选择性有效抑制肿瘤生长。然而，PTT可能导致炎症反应，从而导致肿瘤复发和治疗耐药，这是PTT的主要缺点。本研究成功制备了单分散的钨碳化物纳米颗粒（HfC NPs），用于对癌症的非炎症性光热疗法。HfC NPs具有满意的近红外（NIR）吸收、良好的光热转换效率（PTCE，36.8%）和光热稳定性。此外，由于拥有大的表面积和固有的氧化还原活性位点，HfC NPs表现出优异的抗炎特性，归功于其抗氧化和超氧化物歧化酶（SOD）酶活性。体外和体内实验证实，HfC NPs在近红外激光照射下将光能转化为热能，通过光热疗法杀死癌细胞，并通过抗炎效应获得更好的治疗效果。本研究突出了多功能HfC NPs在非炎症性光热疗法中的出色安全性和疗效。版权所有 © 2023 Elsevier Inc. 保留所有权利。

Photothermal therapy (PTT) effectively suppresses tumor growth with high selectivity. Nevertheless, PTT may cause an inflammatory response that leads to tumor recurrence and treatment resistance, which are the main disadvantages of PTT. Herein, monodisperse hafnium carbide nanoparticles (HfC NPs) were successfully prepared for noninflammatory PTT of cancer. HfC NPs possessed satisfactory near-infrared (NIR) absorption, good photothermal conversion efficiency (PTCE, 36.8 %) and photothermal stability. Furthermore, holding large surface areas and intrinsic redox-active sites, HfC NPs exhibited excellent anti-inflammatory properties due to their antioxidant and superoxide dismutase (SOD) enzymatic activities. In vitro and in vivo experiments confirmed that HfC NPs converted light energy into heat energy upon NIR laser irradiation to kill cancer cells through PTT and achieved a better therapeutic effect by anti-inflammatory effects after PTT. This work highlights that multifunctional HfC NPs can be applied in noninflammatory PTT with outstanding safety and efficacy.Copyright © 2023 Elsevier Inc. All rights reserved.