基于中国典型沿海城市的鱼类消费模式，对不同年龄和性别群体的重金属暴露进行人体生物监测。
Human biomonitoring of heavy metals exposure in different age- and gender-groups based on fish consumption patterns in typical coastal cities of China.
发表日期：2023 Aug 02
作者：
Muhammad Ubaid Ali, Chuan Wang, Yuan Li, Xingang Jin, Shaochen Yang, Li Ding, Lin Feng, Bo Wang, Ping Li
来源：
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
摘要：
本研究旨在根据青岛、厦门和舟山的鱼类消费模式，调查人体头发中的重金属（HMs）浓度。使用酸消化和电感耦合等离子体质谱仪（ICP-MS，NexION 300X，PerkinElmer）确定了（HMs）浓度。使用美国环境保护署（USEPA）描述的风险评估模型进行了健康风险调查。青岛鱼类的重金属浓度顺序为CdCrCu>Pb>Cr>As>Cd的降序排列。研究人口中有28％的人头发中的锌含量超过了安全标准。总体而言，中年人群（19-45岁和45-59岁）的头发中重金属浓度较高，而尤其在女性的情况下，头发中重金属浓度较高。发现头发中的As (0.119; p < 0.05)、Cr (0.231; p < 0.05)和Cu (0.117; p < 0.05)与鱼类消费频率之间存在显著相关性。高鱼类消费频率中As、Cu和Zn的奇险比（>2）较高。发现厦门的人体暴露于Cr的非致癌风险显著 (1.10E+00)，指数值表明非致癌风险在厦门和舟山存在。As对人体暴露的致癌风险（2.50E-05-7.09E-03）指示显著的癌症风险。版权所有© 2023 年作者。由 Elsevier Inc. 发表。保留所有权利。
The study aimed to investigate heavy metals (HMs) concentrations in human hair based on fish consumption patterns in Qingdao, Xiamen, and Zhoushan. The (HMs) concentrations were determined using acid digestion and an inductively coupled plasma mass spectrometer (ICP-MS, NexION 300X, PerkinElmer). The associated health risks were investigated using risk assessment models described by the United States Environmental Protection Agency (USEPA). The order of fish HMs concentration in Qingdao was CdCrCu>Pb>Cr>As>Cd in all three study areas. The hair Zn concentration in 28 % of the studied population exceeded the safety standards. Overall, the hair HMs concentration was found to be high in middle-aged groups (19-45 and 45-59), and the hair HMs concentrations were high, especially in the case of females. A significant correlation was noticed between hair As (0.119; p < 0.05), Cr (0.231; p < 0.05),) and Cu (0.117; p < 0.05),) and fish consumption frequency. High Odd ratios (>2) were noticed for As, Cu and Zn in high fish-eating frequency. A significant non-carcinogenic risk was noticed in human Cr exposure (1.10E+00) in Xiamen, and the hazard index values indicated non-carcinogenic risk in Xiamen and Zhoushan. The carcinogenic risk for human As exposure (2.50E-05-7.09E-03) indicated a significant cancer risk.Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.