我们评估了接受初次手术治疗的宫颈鳞状细胞癌（SCC）患者的临床病理参数，并评估其与生存结果的关系。具体来说，我们评估了淋巴血管浸润（LVI）的程度与生存结果的关系。我们收集了来自10个机构的所有初次手术治疗的宫颈SCC患者的所有可用肿瘤切片，并进行了回顾性分析。我们评估了标准临床病理参数、肿瘤间质和LVI的程度（局灶性：<5个空间，广泛性：≥5个空间）。我们使用Kaplan-Meier方法评估了PFS和OS。我们创建了单变量和多变量Cox比例风险模型，以确定与预后相关的生存风险因素。总共分析了670个肿瘤样本。诊断时的中位年龄为47岁（IQR：38-60），457名患者（72%）患有2018年国际妇产科联合会（FIGO）I期肿瘤，155个肿瘤（28%）为扁平和/或溃疡性。有303个非角化性肿瘤（51%），237个角化性肿瘤（40%），和356个组织学分级为2级的肿瘤（61%）。可量化的LVI出现在321例病例中（51%；23%为局灶性，33%为广泛性）。在关于PFS的多变量分析中，广泛和局灶性的LVI的结果较阴性LVI差（HR：2.38 [95% CI：1.26-4.47]和HR：1.54 [95% CI：0.76-3.11]，分别；P = 0.02）。对于OS，差异未达到统计学意义。LVI的存在是宫颈SCC患者的预后标志物。对LVI的数量化（广泛性 vs. 局灶性 vs. 阴性）可能是肿瘤学结果的重要生物标志物。版权所有 © 2023 Elsevier Inc. 保留所有权利。

We evaluated clinicopathologic parameters of patients with cervical squamous cell carcinoma (SCC) who were treated with initial surgical management and assessed their relation to survival outcomes. Specifically, we evaluated the relation between extent of lymphovascular invasion (LVI) and survival outcomes.All available tumor slides from patients with initially surgically treated cervical SCC were collected from 10 institutions and retrospectively analyzed. Standard clinicopathological parameters, tumor stroma, and extent of LVI were assessed (focal: <5 spaces, extensive: ≥5 spaces). PFS and OS were evaluated using Kaplan-Meier methodology. Univariable and multivariable Cox proportional hazards models were created to determine prognostic survival-related risk factors.A total of 670 tumor samples were included in the analysis. Median age at diagnosis was 47 years (IQR: 38-60), 457 patients (72%) had a 2018 International Federation of Gynecology and Obstetrics (FIGO) stage I tumor, and 155 tumors (28%) were flat and/or ulcerated. There were 303 nonkeratinizing tumors (51%), 237 keratinizing tumors (40%), and 356 histologic grade 2 tumors (61%). Quantifiable LVI was present in 321 cases (51%; 23% focal and 33% extensive). On multivariable analysis for PFS, extensive and focal LVI had worse outcomes compared to negative LVI (HR: 2.38 [95% CI: 1.26-4.47] and HR: 1.54 [95% CI: 0.76-3.11], respectively; P = 0.02). The difference did not reach statistical significance for OS.Presence of LVI is a prognostic marker for patients with cervical SCC. Quantification (extensive vs. focal vs. negative) of LVI may be an important biomarker for oncologic outcome.Copyright © 2023 Elsevier Inc. All rights reserved.