胰腺腺泡的异质性劫持了癌变和稳态。
Pancreatic acinar heterogeneity hijacks carcinogenesis and homeostasis.
发表日期：2023 Aug 03
作者：
Michael Karl Melzer, Alexander Kleger
来源：
Cell Stem Cell
摘要：
在本期期刊中，江氏及其同事采用多种谱系示踪方法，详细研究了Tff2+中转放大类祖细胞在小鼠胰腺腺泡区的作用。该研究揭示了特定祖细胞在稳态稳定和抑制肿瘤特性方面的见解，并报告了关于腺泡细胞的异质性的发现。版权所有© 2023 Elsevier Inc. 保留所有权利。
In this issue, Jiang and colleagues employ multiple lineage-tracing approaches to elaborate on the role of Tff2+ transit-amplifying progenitor cells in the pancreatic acinar compartment of mice. This work provides insights into the steady-state homeostasis and tumor-suppressive features of certain progenitor cells and presents findings on acinar cell heterogeneity.Copyright © 2023 Elsevier Inc. All rights reserved.