胜者通吃：竞争推动胶质瘤发生中的克隆选择。
The winner takes it all: Competition drives clonal selection in gliomagenesis.
发表日期：2023 Jul 22
作者：
Frank Winkler
来源：
CANCER CELL
摘要：
早期肿瘤发生过程中调控克隆动力学和选择的确切机制仍然大多不清楚。Ceresa等人提供了实验和数学证据证明MYC依赖的克隆间竞争是脑肿瘤演化的一个推动力，为现有概念添加了一个赢家/输家的方面。版权所有2023 Elsevier公司，保留所有权利。
The exact mechanisms that govern clonal dynamics and selection during early tumorigenesis remain largely elusive. Ceresa et al. provide experimental and mathematical evidence that MYC-dependent competition between individual clones is one driving force of brain tumor evolution, adding a winner/loser aspect to the picture that complements existing concepts.Copyright © 2023 Elsevier Inc. All rights reserved.