乳腺癌患者存在患原发性卵巢癌（BR→OV）的风险增加，卵巢癌患者存在患原发性乳腺癌（OV→BR）的风险增加。本系统综述总结了发生BR→OV和OV→BR的风险因素。我们检索了PubMed和Embase直到2022年6月。我们确定了符合纳入标准的23篇文章。研究观察到黑人与白人妇女之间的BR→OV风险较低，饮酒、放射疗法和激素治疗、BRCA2与BRCA1、ER/PR阳性与阴性乳腺肿瘤之间的风险较低，以及乳腺/卵巢癌家族史、三阴性与涡轮式乳腺癌、高级别乳腺肿瘤之间的风险较高。患者患有癌症家族史与OV→BR的风险增加相关。肿瘤特征、遗传和家族因素与BR→OV和OV→BR的风险有关。这些结果可以帮助临床医生为乳腺和卵巢癌患者制定决策，包括风险降低策略。版权所有©2023.由Elsevier B.V.出版。

Women with breast cancer have an increased risk of primary ovarian cancer (BR→OV), and women with ovarian cancer have an increased risk of primary breast cancer (OV→BR). This systematic review summarizes risk factors for developing BR→OV and OV→BR.We searched PubMed and Embase until June 2022.We identified 23 articles meeting our inclusion criteria. Studies observed a lower risk of BR→OV for Black versus White women, alcohol consumption, radiotherapy and hormone therapy, BRCA2 versus BRCA1, and ER/PR positive versus negative breast tumors, and a higher risk with family history of breast/ovarian cancer, triple negative versus luminal breast cancer, and higher grade breast tumors. There was an increased risk of OV→BR with family history of cancer.Tumor characteristics, and genetic and familial factors are associated with risk of BR→OV and OV→BR. These results could aid clinicians in decision-making for breast and ovarian cancer patients, including risk-reducing strategies.Copyright © 2023. Published by Elsevier B.V.