肿瘤是全球最令人关注的公共健康问题之一。消化系统肿瘤作为一种发病率和死亡率很高的恶性肿瘤，是人类最常见的恶性肿瘤之一。研究发现，外泌体作为细胞间通信介质，能够携带母细胞的代谢和遗传信息传递给目标细胞。类似地，外泌体参与脂质代谢并调节消化系统肿瘤的多个过程，包括癌细胞之间的信息传递、肿瘤微环境的形成以及转移、侵袭和化疗抵抗等恶性生物学行为。在本综述中，我们首先介绍外泌体在消化系统肿瘤中作为细胞间脂质代谢通讯介质的主要机制。然后，我们介绍了外泌体脂质代谢与多种类型的消化系统肿瘤，包括胃癌、肝细胞癌、胰腺癌和结直肠癌之间的关系。最后，我们总结和展望了外泌体在消化系统肿瘤中的发展和应用前景。进一步研究外泌体作为细胞间脂质代谢调节介质将有助于消化系统肿瘤的准确和高效诊断与治疗。 © 2023 Elsevier Ltd. All rights reserved.

Neoplasms are one of the most concerned public health problems worldwide. Digestive system neoplasms, with a high morbidity and mortality, is one of the most common malignant tumors in human being. It is found that exosomes act as an intercellular communication media to carry the metabolic and genetic information of parental cells to target cells. Likely, exosomes participate in lipid metabolism and regulates multiple processes in digestive system neoplasms, including the information transmission among cancer cells, the formation of neoplastic microenvironment, and the neoplastic biological behaviors like metastasis, invasion, and the chemotherapy resistance. In this review, we firstly introduce the main mechanisms whereas exosomes act as intercellular lipometabolic communication mediator in digestive system neoplasms. Thereafter we introduce the relationship between exosomes lipid metabolism and various type of digestive system neoplasms, including gastric cancer, hepatocellular carcinoma, pancreatic cancer, and colorectal cancer. Eventually, we summarized and prospected the development and implication of exosomes in digestive system neoplasms. The further research of exosomes as intercellular lipid metabolism mediator will contribute to accurate and efficient diagnosis and treatment of digestive system neoplasms.Copyright © 2023 Elsevier Ltd. All rights reserved.