巨噬细胞是具有高度可塑性的免疫细胞，在人体的所有组织和器官中广泛分布。在乳腺肿瘤的免疫微环境的影响下，巨噬细胞分化为多种生发系谱系。它们通过分泌各种细胞因子发挥促肿瘤或抑制肿瘤的效应。炎性凋亡是由Gasdermin家族蛋白介导的，它们在细胞膜上形成孔洞，并引发激烈的炎性反应和细胞死亡。这是机体抵抗感染的重要方式。肿瘤细胞的炎性凋亡可以激活抗肿瘤免疫并抑制肿瘤生长。与此同时，它释放炎症介质并招募肿瘤相关巨噬细胞（TAMs）进行聚集。巨噬细胞作为细胞因子相互作用的"调解者"，间接影响炎性凋亡途径。本文描述了肿瘤相关巨噬细胞在影响乳腺肿瘤细胞炎性凋亡过程中的作用机制，以及其在肿瘤微环境中的关键作用。此外，本文为深入研究如何利用免疫细胞影响乳腺肿瘤并指导抗肿瘤趋势提供了依据，对预防和治疗乳腺肿瘤具有重要意义。视频摘要。©2023. BioMed Central Ltd., part of Springer Nature.

Macrophages are immune cells with high plasticity that are widely distributed in all tissues and organs of the body. Under the influence of the immune microenvironment of breast tumors, macrophages differentiate into various germline lineages. They exert pro-tumor or tumor-suppressive effects by secreting various cytokines. Pyroptosis is mediated by Gasdermin family proteins, which form holes in cell membranes and cause a violent inflammatory response and cell death. This is an important way for the body to fight off infections. Tumor cell pyroptosis can activate anti-tumor immunity and inhibit tumor growth. At the same time, it releases inflammatory mediators and recruits tumor-associated macrophages (TAMs) for accumulation. Macrophages act as "mediators" of cytokine interactions and indirectly influence the pyroptosis pathway. This paper describes the mechanism of action on the part of TAM in affecting the pyroptosis process of breast tumor cells, as well as its key role in the tumor microenvironment. Additionally, it provides the basis for in-depth research on how to use immune cells to affect breast tumors and guide anti-tumor trends, with important implications for the prevention and treatment of breast tumors. Video Abstract.© 2023. BioMed Central Ltd., part of Springer Nature.