人参源类似于外泌体的纳米颗粒通过主动穿越血脑屏障和肿瘤微环境调节，发挥了抗胶质瘤的作用。
Anti-glioma effect of ginseng-derived exosomes-like nanoparticles by active blood-brain-barrier penetration and tumor microenvironment modulation.
发表日期：2023 Aug 04
作者：
Jisu Kim, Ying Zhu, Sunhui Chen, Dongdong Wang, Shuya Zhang, Jiaxuan Xia, Shiyi Li, Qiujun Qiu, Hyukjin Lee, Jianxin Wang
来源：
Brain Structure & Function
摘要：
抑制肿瘤生长和规范肿瘤微环境（TME）中的免疫反应是改善癌症治疗的关键问题。然而，在治疗胶质瘤时，有效的纳米医学因为血脑屏障（BBB）的存在而受到限制。我们先前证明了纳米大小的人参来源的类似外泌体样纳米颗粒（GENs），由包括各种生物活性成分的磷脂组成，并评估了抗肿瘤免疫反应对T细胞和T调节细胞（Tregs）的抑制作用。研究发现，GENs 对BBB 和胶质瘤的增强靶向能力导致了显著的治疗效果，并在 TME 中表现出强效的招募 M1型巨噬细胞表达。在体外和体内实验证明 GENs 是胶质瘤治疗中的成功候选物，具有抑制胶质瘤进展和调节肿瘤相关巨噬细胞（TAMs）的卓越潜力。© 2023. BioMed Central Ltd., part of Springer Nature.
Inhibition of tumor growth and normalization of immune responses in the tumor microenvironment (TME) are critical issues for improving cancer therapy. However, in the treatment of glioma, effective nanomedicine has limited access to the brain because of the blood-brain barrier (BBB). Previously, we demonstrated nano-sized ginseng-derived exosome-like nanoparticles (GENs) consisting of phospholipids including various bioactive components, and evaluated anti-tumor immune responses in T cells and Tregs to inhibit tumor progression. It was found that the enhanced targeting ability of GENs to the BBB and glioma induced a significant therapeutic effect and exhibited strong efficacy in recruiting M1 macrophage expression in the TME. GENs were demonstrated to be successful candidates in glioma therapeutics both in vitro and in vivo, suggesting excellent potential for inhibiting glioma progression and regulating tumor-associated macrophages (TAMs).© 2023. BioMed Central Ltd., part of Springer Nature.