FIGO 1B1期宫颈癌的标准手术治疗是开放式根治手术。然而，越来越多的证据表明，对于小肿瘤，较保守的方法可以将生育影响最小化，而不会对长期的肿瘤治疗结果产生影响。我们研究的目标是在延长后续随访的基础上，呈现接受保守治疗的小量1B1期疾病患者的生存和产科结果。所有在2000年12月至2021年12月期间，在北方妇科肿瘤中心接受治疗的FIGO 1B1期癌症患者，并且在环扣活检标本中估计的肿瘤体积<500 mm3，都纳入了该研究。其临床病理和人口统计数据与详细的随访和产科结果及一级护理和死亡登记一起被汇总。共有117名患者接受了小体积1B1期疾病的保守手术治疗。其中58人（49.5%）接受了与LLETZ相结合的保留生育机会的保守治疗，而59人（50.5%）接受了简化子宫切除术。总体而言，在111名（117人中的95%）患者接受了双侧盆腔淋巴结清扫，并识别出1个阳性淋巴结。在中位随访时间为8.5年（1-20年）的过程中，没有因宫颈癌相关而死亡，发现了1次复发。在接受LLETZ手术的患者中记录了17次妊娠，出生了17名活产婴儿。未观察到第二孕期流产，有一例早产（36周）。对于小体积1B1期宫颈癌而言，非根治性手术结合负性盆腔淋巴结清扫确保了优异的生存率，同时不影响产科结果。如果这些结果由正在进行中的前瞻性研究得到验证，这些患者的根治性手术可能可以避免。版权所有© 2023 Elsevier Inc. 保留全部权利。

Standard surgical treatment of FIGO stage 1B1 cervical cancer is open radical surgery. However, there is increasing evidence that for small tumours a more conservative approach can minimise fertility consequences without impacting on long term oncologic outcomes. The objective of our study is to present survival and obstetric outcomes following extended follow-up for patients who underwent conservative management of small-volume stage 1B1 disease.All patients with FIGO stage 1B1 cancer and estimated tumour volume of <500 mm3 in a loop biopsy specimen treated in Northern Gynaecological Oncology Centre between December 2000 and December 2021, were included in the study. Clinico-pathological and demographic data were collated alongside detailed follow-up and obstetric outcomes in conjunction with primary care and death register.117 patients underwent conservative surgery for small volume stage 1B1 disease. 58 (49.5%) underwent fertility sparing conservative management with LLETZ while 59 (50.5%) underwent simple hysterectomy. Overall, 95% (111/117) of the patients underwent bilateral pelvic lymphadenectomy and 1 positive node was identified. There was no death related to cervical cancer and 1 recurrence identified during a median follow up of 8.5 years (1-20). 17 pregnancies have been recorded in patients underwent LLETZ and 17 live babies were born. No second trimester miscarriages were noted and there was one preterm delivery (36 weeks).Non-radical surgery with negative pelvic lymphadenectomy for smallvolume stage 1B1 cervical cancer ensures excellent survival without compromising obstetric outcomes. Should these results be verified by the ongoing prospective studies, radical surgery for these patients may be avoided.Copyright © 2023 Elsevier Inc. All rights reserved.