比较滤泡手术和晶体提取术对于年轻患者的医疗控制方面的闭角病房性青光眼（ACG）的效果。回顾性、非随机、对比性干预研究。我们回顾了以下情况的病例：（1）年龄≤ 40岁，（2）诊断为无白内障的闭角病房性青光眼，包括原发性闭角型青光眼（PACG），小眼闭角性青光眼和合并视网膜病变的闭角病房性青光眼，（3）进行滤泡手术或晶体提取术的闭角病房性青光眼。主要观察指标包括术后早期（1周内）和晚期（>3个月）随访时的眼内压（IOP）、药物数量、最佳矫正视力和严重并发症。共有130名年轻患者的160只眼的数据可用。其中76只PACG，12只小眼闭角性青光眼和26只合并视网膜病变的闭角病房青光眼接受了滤泡手术，而22只PACG，12只小眼闭角性青光眼和12只合并视网膜病变的闭角病房性青光眼接受了晶体提取术。总体而言，在每个ACG亚组中，滤泡手术和晶体提取术都在术后晚期显著减轻了眼内压和药物，并且两种治疗的完全成功率相似（P > . 05）。关于安全性，滤泡手术和合并视网膜病变的患者是与术后恶性青光眼相关的独立因素（在两个多变量逻辑回归模型中均为P < . 05）。本研究强调在医疗控制不佳的年轻ACG患者中，晶体提取术的疗效与滤泡手术类似，但晶体提取术更安全，尤其是对于合并视网膜病变的年轻ACG患者。版权所有©2023 Elsevier Inc.发表。

To compare the effect of filtering surgery versus clear lens extraction in young patients with medically uncontrolled angle-closure glaucoma (ACG).Retrospective, non-randomized, comparative, interventional study.We reviewed the medical charts of patients with the following scenarios: (1) age ≤ 40 years, (2) diagnosis of ACG without cataract, including primary angle-closure glaucoma (PACG), nanophthalmic ACG and ACG combined with retinal dystrophies, (3) ACG undergoing filtering surgery or clear lens extraction. The main outcomes including intraocular pressure (IOP), number of medications, best-corrected visual acuity, and severe complications were extracted at the postoperative early (within 1 week) and late stage (>3 months) follow-up.Data from 160 eyes of 130 young patients with ACG were available. Eyes with 76 PACG, 12 nanophthalmic ACG, and 26 ACG with retinal diseases underwent filtering surgery, while eyes with 22 PACG, 12 nanophthalmic ACG, and 12 ACG with retinal diseases received clear lens extraction. Overall, filtering surgery and clear lens extraction resulted in significant but comparable IOP and drug reductions at the postoperative late stage in each ACG subgroup, with similar complete success rates between two treatments (all P >.05). Regarding the safety, filtering surgery and patients with retinal diseases were independent factors associated with postoperative malignant glaucoma (P <.05 in both multivariable logistic regression models).This study highlights that the efficacy of clear lens extraction is comparable to that of filtering surgery in medically uncontrolled young ACG, but clear lens extraction is safer, especially for young ACG comorbid with retinal diseases.Copyright © 2023. Published by Elsevier Inc.