FTO基因rs9939609多态性对结肠直肠癌和不同类型脂肪摄入之间关联的影响：一项病例对照研究。
The effect of FTO gene rs9939609 polymorphism on the association between colorectal cancer and different types of dietary fat intake: a case-control study.
发表日期：2023 Aug 05
作者：
Azadeh Hajipour, Naeemeh Hassanpour Ardekanizadeh, Zahra Roumi, Soheila Shekari, Bahareh Aminnezhad Kavkani, Seyedeh Hayedeh Mousavi Shalmani, Bojlul Bahar, Shirin Tajadod, Marjan Ajami, Ghasem Azizi Tabesh, Maryam Gholamalizadeh, Saeid Doaei
来源：
Food & Function
摘要：
结直肠癌（CRC）是世界上最常见的癌症之一。一些膳食因素，如脂肪摄入，已被确定为CRC的危险因素。本研究旨在调查脂肪质量和肥胖相关（FTO）基因rs9939609多态性对CRC与不同类型膳食脂肪之间关系的影响。这项病例-对照研究在伊朗德黑兰对135名CRC患者和294名健康对照进行。从所有参与者中收集了关于人口学因素、人体测量、体力活动、不同类型膳食脂肪摄入和FTO基因rs9939609多态性的数据。使用不同的逻辑回归模型评估了不同FTO基因型人群之间膳食脂肪摄入与癌症的关联。患病组和对照组在TT（7.2±3.46 vs. 5.83±3.06 g/d, P=0.02）和AA/AT基因型（8.7±6.23 vs. 5.57 ±3.2 g/d, P<0.001）的人中都高于对照组。在FTO rs9939609多态性的AA/AT基因型携带者中，发现了CRC与油酸摄入量（OR=1.12，CI95% 1.03-1.21，P=0.01）和胆固醇摄入量（OR=1.01，CI95% 1.00-1.02，P=0.01）之间的正相关，这在调整了年龄、性别、体力活动、饮酒、吸烟、热量摄入和体重指数后得到了证实。在FTO风险等位基因携带者中，胆固醇和油酸的摄入量越高，患CRC的风险也越高。CRC与膳食脂肪的关联可能受到FTO基因型的影响。进一步的纵向研究需要对这些发现进行证实。© 2023. 日本生理人类学学会。
Colorectal cancer (CRC) is one of the most common cancers in the world. Some dietary factors such as fat intake have been identified as the risk factors for CRC. This study aimed to investigate the effect of fat mass and obesity-associated (FTO) gene rs9939609 polymorphism on the association between CRC and different types of dietary fats.This case-control study was performed on 135 CRC cases and 294 healthy controls in Tehran, Iran. Data on demographic factors, anthropometric measurements, physical activity, the intake of different types of dietary fats, and FTO gene rs9939609 polymorphism was collected from all participants. The association between cancer and dietary fat intake in individuals with different FTO genotypes was assessed using different models of logistic regression.Oleic acid intake was higher in the case group compared to the control group in both people with TT (7.2±3.46 vs. 5.83±3.06 g/d, P=0.02) and AA/AT genotypes (8.7±6.23 vs. 5.57 ±3.2 g/d, P<0.001). Among carriers of AA/AT genotypes of FTO rs9939609 polymorphism, a positive association was found between CRC and higher intakes of oleic acid (OR=1.12, CI95% 1.03-1.21, P=0.01) and cholesterol (OR=1.01, CI95% 1.00-1.02; P=0.01) after adjusting for age, sex, physical activity, alcohol use, smoking, calorie intake, and body mass index.Higher intakes of cholesterol and oleic acid were associated with a higher risk of CRC in FTO-risk allele carriers. The association of CRC and dietary fat may be influenced by the FTO genotype. Further longitudinal studies are warranted to confirm these findings.© 2023. The Japan Society of Physiological Anthropology.