胆管癌（CCA）是一种常见且致命的恶性肿瘤，起源于胆管上皮细胞。已经使用了多种肿瘤生物标志物进行其临床筛查，如碳水化合物抗原19-9和癌胚抗原。本研究旨在通过综合生物信息学分析证明相关基因CMT1A重复区段转录物15（CDRT15）对CCA预后的价值。我们从癌症基因组图谱数据库中获取了具有CCA的患者的CDRT15表达数据和临床信息。然后，我们通过差异表达基因分析、基因集富集分析、统计分析等处理了数据。基因本体富集分析旨在探索与基因相关蛋白的功能。单样本基因集富集分析用于分析CDRT15与免疫细胞之间的相关性。最后，我们构建了一个预测CCA患者预后的模型。癌症基因组图谱数据库中的数据分析表明CDRT15在CCA组织中高表达。我们进行了免疫浸润的相关性分析，显示CDRT15主要与免疫/炎症反应相关。ROC曲线显示CDRT15可以作为CCA的诊断标志物。随后，预后分析表明高CDRT15表达与恶化的总生存率有关，高CDRT15表达的患者可能有不良预后。 CDRT15在CCA中高表达，因此我们确定CDRT15可以作为有效的患者生物标志物。 CDRT15表达与CCA预后呈负相关。CDRT15可能参与CCA的免疫浸润过程。版权所有 © 2023 作者。Wolters Kluwer Health, Inc. 发表。

Cholangiocarcinoma (CCA) is a common and lethal malignant tumor originating from bile duct epithelial cells. Various tumor biomarkers have been used for its clinical screening, such as carbohydrate antigen 19-9 and carcinoembryonic antigen. This study aimed to demonstrate the value of associated genes-CMT1A duplicated region transcript 15 (CDRT15) for prognosis of CCA by integrated bioinformatics analysis. We obtained CDRT15 expression data and clinical information on patients with CCA from The Cancer Genome Atlas database. Then, we processed the data by differentially expressed gene analysis, gene set enrichment analysis, statistical analysis, etc. Gene Ontology enrichment analysis was aimed to explore the function of gene-related proteins. Single-sample gene set enrichment analysis was used to analyze the correlation between CDRT15 and immune cells. Finally, we constructed the nomogram to predict the prognosis of patients with CCA. The analysis of data in The Cancer Genome Atlas database revealed that CDRT15 was overexpressed in CCA tissues. We performed the interrelation analysis of immune infiltration, showing that CDRT15 are mainly associated with the immune/inflammatory response. ROC curve showed that CDRT15 can be a diagnostic marker of CCA. Subsequently, the prognostic analysis showed that the high expression of CDRT15 was correlated with the poor OS, and patients with high CDRT15 expression may have a poor prognosis. CDRT15 is more highly expressed in CCA, thus we identified that CDRT15 could be an efficient biomarker for patients. CDRT15 expression was negatively correlated with prognosis of CCA. CDRT15 may be involved in the immune infiltration process of CCA.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.