胃癌（GC）是与癌症相关的健康负担的一个持续关注的问题。有价值的预测和预后指标支持早期诊断和改善结局。免疫逃逸和炎症是重要的癌症特征。某些癌症报道了血小板/淋巴细胞比值（PLR）和中性粒细胞/淋巴细胞比值（NLR）的预后和诊断价值。但这些廉价且方便的指标远未得到临床应用。因此，有必要研究这些指标在GC上的变化，以推行在临床使用这些指标。本研究招募了77名刚诊断为GC的住院患者和90名健康个体。参与者的临床和临床前数据收集自医院信息管理系统。本研究获得了越南军事医科大学伦理委员会的批准。数据分析使用STATA 14.0版本和GraphPad Prism 8.0。与健康个体相比，GC患者的白细胞计数、中性粒细胞、血小板、PLR和NLR显著增加，淋巴细胞减少，报告了免疫系统的改变。与早期GC相比，这些指标在晚期GC上升。我们的受试者工作特征曲线分析显示PLR（截断值为135.0）和NLR（截断值为2.0）在GC诊断中具有显著的特异性和敏感性，受试特征曲线下面积分别为84.74％和85.17％，P<.0001。此外，我们的结果报道了PLR和NLR的上升趋势以及从临床症状到诊断的时间缩短。PLR和NLR在GC的诊断和预后中具有显著的特异性和敏感性。版权所有© 2023 作者。由Wolters Kluwer Health，Inc.出版。

Gastric cancer (GC) is the remaining concern of cancer-associated health burden. Valuable predictive and prognostic indicators support the early diagnosis and improve outcome. Immune escape and inflammation are important cancer hallmarks. The prognostic and diagnostic value of platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) was reported in some cancers. But these cheap and convenient indexes are far from clinical use. Thus, investigation the alteration of those index on GC is needed to impose the use of those indexes in clinic. The study recruited seventy-seven hospitalized patients newly diagnosed with GC and 90 healthy individuals. The clinical and preclinical data of participants were collected from Hospital Information Management system. This study were approved by the Ethical Committee, Vietnam Military Medical University. The data were analyzed on STATA version 14.0 and GraphPad Prism 8.0. The alteration of immunological system was reported by significantly higher white blood cell count, neutrophils, platelets, PLR, and NLR as well as decreased lymphocytes on GC, compared to healthy individuals. Those indexes were elevated on advanced stage GC, compared to early stage GC. Our receiver operating characteristic curve analysis showed the significant specificity and sensitivity of PLR (cutoff 135.0) and NLR (cutoff 2.0) on GC diagnosis with respective area under receiver operating characteristic curve of 84.74% and 85.17%, P < .0001. Besides, our results reported the tendency of increased PLR and NLR and short time from clinical signs to being diagnosed. PLR and NLR have significant specificity and sensitivity in diagnosis and prognosis of GC.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.