在过去的十年中，累积的研究报告了非规范的巨噬自噬/自噬的存在，这种自噬特点是利用了自噬机制和在多种情况下发挥作用但不涉及溶酶体降解的不同组分。非规范自噬之一是分泌性自噬，它促进了多种货物的分泌。在高等人最近的一项工作中，内质网膜蛋白STING1被鉴定为分泌性自噬的一种新型底物。活化的STING1的分泌是通过其装配到伴随小排(Packing into the rafeesome)中实现的，这是一种新鉴定的细胞器，由RAB22A介导的非规范自噬体和早期内体融合形成。此外，富含活化STING1的胞外囊泡在受体细胞中诱导抗肿瘤免疫，这个过程可能由RAB22A促进。

Over the past decade, accumulated studies have reported the presence of non-canonical macroautophagy/autophagy characterized by the shared usage of the autophagy machinery and distinct components that function in multiple scenarios but do not involve lysosomal degradation. One type of non-canonical autophagy is secretory autophagy, which facilitates the secretion of various cargoes. In a recent work from Gao et al. the ER-membrane protein STING1 has been identified as a novel substrate of secretory autophagy. The secretion of activated STING1 is mediated by its packing into the rafeesome, a newly identified organelle formed upon the fusion of RAB22A-mediated non-canonical autophagosome with an early endosome. Moreover, extracellular vesicles containing activated STING1 induce antitumor immunity in recipient cells, a process potentially promoted by RAB22A.