甲基供体营养素摄入与结直肠癌（CRC）风险的流行病学证据仍不一致。我们旨在研究B族维生素、蛋氨酸、总胆碱和甜菜碱的摄入与CRC风险的关系，研究对象为巴斯克地区CRC筛查计划中的一群人口。这项观察性研究包括308例CRC患者和308例年龄性别匹配的对照组。在招募期间，收集了饮食、人体测量、生活方式、社会经济学、人口统计学和健康状况信息。采用条件 logistic 回归估计CRC风险的比值比（ORs）。调整后的ORs显示，胆碱和甜菜碱摄入量越高，CRC风险越低（p < 0.05）。在进一步调整叶酸后，高胆碱和甜菜碱摄入仍与降低CRC风险相关（调整模型胆碱，第三分位数对第一分位数 OR =0.45，95% CI 0.26-0.80，p = 0.006；甜菜碱，第三分位数对第一分位数OR =0.27，95% CI 0.16-0.47，p < 0.001）。至于其他营养素，我们的发现提示高摄入水平与降低CRC风险无显著关联。我们的数据表明，在研究对象中，胆碱和甜菜碱摄入对CRC风险有影响。© 2023. 作者。

Epidemiologic evidence for the association between methyl-donor nutrient intake and colorectal cancer (CRC) risk remains inconclusive. We aimed to examine the relationship between intake of vitamins of the B group, methionine, total choline and betaine and CRC risk, in a population from the CRC screening programme in the Basque Country.This observational study included 308 patients with CRC and 308 age- and sex-matched subjects as controls. During recruitment, dietary, anthropometric, lifestyle, socioeconomic, demographic, and health status information was collected. Conditional logistic regression was used to estimate the odds ratios (ORs) for CRC risk.The adjusted ORs for CRC risk decreased with higher intakes of choline and betaine (p < 0.05). After further adjustment for folate, high intake of choline and betaine remained associated with a reduced CRC risk (adjusted model for choline, OR third tertile vs first tertile = 0.45, 95% CI 0.26-0.80, p = 0.006; for betaine, OR third tertile vs first tertile = 0.27, 95% CI 0.16-0.47, p < 0.001). Regarding the other nutrients, our findings indicated a non-significant decrease in CRC risk with the high level of intake.Our data suggest that choline and betaine intake influence CRC risk in the studied population.© 2023. The Author(s).