COVID后综合征可能会影响胃肠道，然而，COVID后综合征的风险因素仍然未知。本研究旨在确定与COVID后综合征相关的最常见的胃肠道症状、异常实验室检测结果和风险因素。在这项回顾性研究中，我们纳入了2020年10月至2022年9月间在Semmelweis大学外科、移植和胃肠病学科就诊的79名患者。我们调查了临床数据和实验室检测结果，并确定了主要的风险因素。大部分患者为女性（46/79），平均年龄为47.6岁，患者超重（BMI：26.3 kg/m2）。最常见的合并症包括心血管疾病（21/79）、高血压（20/79）、糖尿病（11/79）和恶性肿瘤（9/79）。胃镜的典型适应证包括消化不良（16/79）和上腹痛（10/79）。结肠镜的最常见适应证是腹泻（29/79）和体重减轻（28/79）。在异常的实验室检测结果中，COVID后患者的肝酶水平（GOT：83.5 U/L，GPT：85 U/L，GGT：70 U/L）和铁蛋白（351.5 ng/mL）较高。通过胃镜、结肠镜和腹部超声检查诊断出的典型疾病包括胃食管反流病（11/26）、肠易激综合征（2/19）和弥漫性肝损害等。未接种COVID-19疫苗的患者数量较接种者更高（58% vs. 29%）。接种疫苗的患者中，有12名患者接种了mRNA疫苗（10名辉瑞-联合利华，2名摩德纳）和6名患者接种了病毒载体疫苗（2名阿斯利康，4名俄罗斯斯普京克V）。我们确定女性性别、肥胖、心血管疾病、癌症、高血压和糖尿病是COVID后综合征的主要风险因素。接种疫苗的状态可能可以预防COVID后胃肠道症状。《医学周报》. 2023; 164(31): 1206-1212.

Post-COVID syndrome may affect the gastrointestinal tract. However, risk factors of post-COVID syndrome are still unknown.We aimed to identify the most common gastrointestinal symptoms, abnormal laboratory findings and risk factors relevant to post-COVID syndrome.In this retrospective study, we included 79 patients admitted to Semmelweis University Department of Surgery, Transplantation and Gastroenterology between October 2020 and September 2022. We investigated clinical data, laboratory findings and determined the major risk factors.Most of the patients were women (46/79), their mean age was 47.6 years and patients were overweight (BMI: 26.3 kg/m2). The most common comorbidities were cardiovascular diseases (21/79), hypertension (20/79), diabetes (11/79) and malignant diseases (9/79). Typical indications for gastroscopy were dyspepsia (16/79) and epigastric pain (10/79). The most common indications for colonoscopy were diarrhea (29/79) and weight loss (28/79). Among abnormal laboratory findings, liver enzymes levels (GOT: 83.5 U/L, GPT: 85 U/L, GGT: 70 U/L) and ferritin (351.5 ng/mL) were higher in post-COVID patients. Typical conditions diagnosed by gastroscopy, colonoscopy and abdominal ultrasound were gastroesophageal reflux disease (11/26), irritable bowel syndrome (2/19) and diffuse hepatic lesions, respectively. The number of unvaccinated patients was higher compared to those receiving any COVID-19 vaccines (58% vs. 29%). Of the vaccinated patients, 12 patients received mRNA vaccines (10 Pfizer-BioNTech, 2 Moderna) and 6 patients received viral vector vaccines (2 AstraZeneca, 4 Sputnik V).We identified female gender, obesity, cardiovascular diseases, cancer, hypertension and diabetes as major risk factors of post-COVID syndrome. Vaccinated status may prevent post-COVID gastrointestinal symptoms. Orv Hetil. 2023; 164(31): 1206-1212.