结直肠癌是与癌症相关死亡的第二大原因，给社会造成了巨大的负担。定期筛查和新兴的分子肿瘤标记物对于检测结直肠癌的进展和发展具有重要意义。二硫化物失配死亡（disulfidptosis）是一种由细胞中异常积累的二硫化合物引发的编程细胞凋亡，进而诱导二硫化物压力。目前对于这种机制与结直肠癌的相关讨论尚未见到。我们使用生物信息学方法对与二硫化物失配死亡相关的结直肠癌亚型进行分类。通过对亚型间差异表达基因的二次聚类，我们确定了二硫化物失配死亡亚型的特征基因，构建了一个预后模型，并通过临床验证寻找潜在的生物标志物。利用从文献中收集到的与二硫化物失配死亡相关的基因，我们将公共数据库中的结直肠癌患者分类为三个亚型。通过聚类分析，确定了亚型间差异表达基因的三个基因亚型，并筛选出八个特征基因用于构建预后模型。二硫化物失配死亡机制在结直肠癌患者分类中具有重要价值，而基于该机制选择的特征基因可作为结直肠癌的新潜在生物标志物。 ©2023年。作者，授予Springer-Verlag GmbH Germany独家许可，Springer Nature的一部分。

Colorectal cancer is the second leading cause of cancer-related deaths, which imposes a significant societal burden. Regular screening and emerging molecular tumor markers have important implications for detecting the progression and development of colorectal cancer. Disulfidptosis is a newly defined type of programmed cell death triggered by abnormal accumulation of disulfide compounds in cells that stimulate disulfide stress. Currently, there is no relevant discussion on this mechanism and colorectal cancer.We classified the disulfidptosis-related subtypes of colorectal cancer using bioinformatics methods. Through secondary clustering of differentially expressed genes between subtypes, we identified characteristic genes of the disulfidptosis subtype, constructed a prognostic model, and searched for potential biomarkers through clinical validation.Using disulfidptosis-related genes collected from the literature, we classified colorectal cancer patients from public databases into three subtypes. The differentially expressed genes between subtypes were clustered into three gene subtypes, and eight characteristic genes were screened to construct a prognostic model.The disulfidptosis mechanism has important value in the classification of colorectal cancer patients, and characteristic genes selected based on this mechanism can serve as a new potential biological marker for colorectal cancer.© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.